Endocrine Abstracts

Introduction: The association between acromegaly and neoplasia is rare but described, particularly colorectal and thyroid cancers, especially since the disease is not controlled.Observation: We report the case of a 44-year-old patient, hypertensive, diabetic, followed for acromegaly clinically retained in the face of dysmorphic syndrome, an IGF1 at 3.5 times normal on a pituitary macroadenoma of 9.9x13x9.3. The assessment of the impact of this acromegaly...

Introduction: Adrenal myelolipoma is a rare, benign and nonfunctional tumor composed of mature adipose and hematopoietic cells. It is often of incidental finding (8%) and the diagnosis is based on radiological imaging. We report two cases of giant adrenal myelolipoma and discuss the diagnostic and therapeutic aspects of this pathology.Observation: Patient D.K 40 years old, hospitalized for adrenal mass revealed by right back pain radiating to the right h...

Background: Von Hippel–Lindau (VHL) is a rare, autosomal dominant syndrome characterized by the development of highly vascularized tumors in multiple organs. VHL affects approximately 1 in 35,000 live births. Tumors associated with VHL include hemangioblastom of the retina and central nervous system, pheochromocytomas, endolymphatic sac tumors of the middle ear, and epididymal or round ligament cysts. In 80% of patients, VHL disease is familial caused by mutations in the ...

Introduction: Proximal myopathy presents as symmetrical weakness of proximal upper and/or lower limbs. There is a broad range of underlying causes including drugs, alcohol, endocrine and metabolic myopathies such as primary hyperparathyroidism.Observation: We describe a 48-year-old male, hospitalised in neurology departement for exploration of severe proximal myopathy. Cliniquely, he presented progressive debilitating muscle weakness, severe muscle wasti...

Introduction: Prolactin-secreting tumors or prolactinomas comprise the most common pituitary tumor type, acconting of 47-66% of all pituitary tumors. These tumors can be treated with dopaminergic drugs (DA) however 10-15% of prolactinomas are DA resistant.Case 1: A 39 years old man followed for a geant agressif prolactinoma discovered following a progressive decline in visual acuity and associated with visual impairment (diplopia), the MRI of the sellar ...

Introduction: Pituitary adenomas, more recently referred to as pituitary neuroendocrine tumors (PitNets) from other organs, are common neoplasms comprising 10 to 20% on intracranial tumors. Null cell adenoma is a diagnosis of exclusion that requires immunonegativity for all adenohypophyseal hormones and a lack of cell type-specific transcription factors. It represents 0,6% of all pituitary tumors. Case: A 55 years old women with a history of treated thyr...

Introduction: Pheochromocytomas and paragangliomas (PPGLs) are chromaffin cell tumors that arise from neuroectodermal cells. These tumors are characterized by a very heterogeneous natural history and an unpredictable ability to metastasize. The rate of metastatic disease ranges from lessthan 1% to 79%, depending on tumor site and size, age at diagnosis and genotype.30% are considered to be hereditary. Primary hyperparathyroidism can be associated with PPLGs. We report a case o...

Introduction: The Munchausen syndrome, also known as factitious disorder, involves a compulsion to simulate illness or trauma. Individuals may go as far as taking medication or inflicting harm on their bodies to evoke compassion. The aim of this report is to illustrate the example of factitious hypoglycemia, one of the most common forms of factitious disorders in the endocrine-metabolic field, accounting for 4-11% of all non-diabetic hypoglycemias.Observ...

Introduction: Paragangliomas are chromaffin cell tumors that arise from neuroectodermal cells. Multiple paragangliomas in the same patient are highly uncommon. These tumors have a variable clinical picture, and a very heterogeneous evolution. The pulmonary localization is one of the most frequent, representing 20 to 30% of all neuroendocrine tumors. The silent or aggressive character causes problems in diagnosis, management and prognosis.Case report: We ...

Introduction: Pituitary abscess (PA) is a rare accounting for 0,2-1% of all sellar lesions, it is generally classified as primary or secondary according to their etiopathogenesis. Case: A 20-year-old female with a history of vulvitis a year ago, dental abscesses on multiple dental caries who presented 05 months ago with intracranial hypertension syndrome in a febrile context. One-month later amenorrhea sets in as well as polyuropolydeptic syndrome, hormo...