Searchable abstracts of presentations at key conferences in endocrinology

ea0070oc5.3 | Thyroid | ECE2020

Acute pancreatitis associated with methimazole treatment: A retrospective analysis of administrative health databases conducted in the Piedmont Region, Italy

Caputo Marina , Pecere Alessandro , Sarro Andrea , Zibetti Angelica , Marzullo Paolo , Aimaretti Gianluca , Barone-Adesi Francesco

Purpose: Methimazole (MMI) is a widely used antithyroid agent for first-line treatment of hyperthyroidism. A warning has been recently issued by the European Medicine Agency (EMA) regarding a potential increased risk of acute pancreatitis (AP) in MMI users, based on evidences from published case reports and post-marketing surveillance. The aim of this study was to investigate the association between MMI treatment and the diagnosis of AP in drug users.Mat...

ea0022p421 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Thyroid Incidentaloma identified by 18F-Fluorodeoxyglucose Positron Emission Tomography with CT (FDG-PET/CT): clinical relevance

Pagano Loredana , Sama MariaTeresa , Rudoni Marco , Belcastro Sara , Busti Arianna , Caputo Marina , Inglese Eugenio , Aimaretti Gianluca

Thyroid incidentalomas was defined as newly identified thyroid lesions encountered during imaging study for non-thyroid diseases. In the last years, the use of FDG-PET/CT for staging of metastatic diseases was increased. The aim of this retrospective study was to evaluate the FDG-PET/CT uptake, to identify a SUVmax cut off predictive of malignancy and to determine the FDG-PET/CT prognostic role in patients with thyroid incidentalomas. 42 patients (ptx) with incidental thyroid ...

ea0022p668 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

IGF1 levels as predictor factor of metabolic derangement in adult patients with severe GH deficiency

Gasco Valentina , Beccuti Guglielmo , Rovere Silvia , Marotta Filippa , Aimaretti Gianluca , Maccario Mauro , Grottoli Silvia , Ghigo Ezio

GH deficiency (GHD) in adults leads to impairment in body composition and function, as well as to deranged lipoprotein and carbohydrate metabolism implying increased cardiovascular morbidity. The morphologic and metabolic alterations in GHD syndrome are more marked in patients with the most severe GHD, even when evaluated by maximal provocative test such as GHRH + arginine. IGF1 synthesis and secretion are function of the GH status but also of major metabolic factors such as i...

ea0020p553 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Ghrelin as new provocative test for the diagnosis of GH deficiency in adults

Gasco Valentina , Rovere Silvia , Beccuti Guglielmo , Broglio Fabio , Aimaretti Gianluca , Grottoli Silvia , Casanueva Felipe , Ghigo Ezio

ITT is the test of reference for the diagnosis of adult GH deficiency (GHD), but it is recognized that also GHRH in combination with arginine (ARG) or GH secretagogues (GHS) are equally reliable tests. It has also been suggested that testing with GHS would represent a potent stimulus exploring also the integrity of hypothalamic pathways controlling somatotropic function. We therefore aimed to clarify the diagnostic reliability of testing with ghrelin, the natural GHS. We studi...

ea0073aep201 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Liraglutide for weight management in syndromic obesity: effects in overgrowth adult Beckwith–Wiedemann syndrome

Caputo Marina , Daffara Tommaso , Bellone Simonetta , Mancioppi Valentina , Marzullo Paolo , Aimaretti Gianluca , Prodam Flavia

ContextGenetic obesity, including syndromic and non-syndromic forms, represent a minority of cases but gene dysregulations make their management particularly difficult. Among them, Beckwith–Wiedemann syndrome (BWS) is a multisystem human genomic imprinting disorder characterized by overgrowth, macroglossia, abdominal wall defects, hemi hyperplasia, enlarged abdominal organs, and an increased risk of embryonal tumours. The syndrome is caused by genet...

ea0099p271 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Obesity in transition towards diabesity: anthropometric determinants and markers of tissue damage

Mele Chiara , Mai Stefania , Borrini Martina , Cavigiolo Beatrice , Caputo Marina , Scacchi Massimo , Aimaretti Gianluca , Marzullo Paolo

Background: The term ‘Diabesity’ defines the complex relationship between obesity and type 2 diabetes mellitus (T2DM), that involves the convergent role of insulin resistance and chronic inflammation in amplifying the risk of systemic complications. To date, this link has not been fully characterized in terms of markers of tissue damage. The aim of this study was to investigate the association between the newly diagnosed glycemic alterations and the biomarkers of tis...

ea0099p485 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Diabetes mellitus in patients undergoing pancreatectomy (T3cDM): preliminary data analysis

Borrini Martina , Mele Chiara , Maroso Fabio , Pitino Rosa , Vimercati Davide , Romito Raffaele , Aimaretti Gianluca , Marzullo Paolo

Rationale and purpose: Glucose tolerance often changes in patients with pancreatic lesions and usually worsens after distal pancreatectomy; however, factors affecting interindividual variation in progression are unclear. Our study aimed to investigate the glyco-metabolic status in a series of patients undergoing pancreatic resection for treatment of benign or malignant lesions and risk factors involved in the developing T3cDM.Methods: We conducted an obs...

ea0081p474 | Thyroid | ECE2022

Potential risk factors for post-treatment recurrence in patients with intermediate-risk differentiated thyroid carcinoma

Rossi Mattia , Mele Chiara , Rossetto Giaccherino Ruth , Brero Denise , Marsan Giulia , Aimaretti Gianluca , Ghigo Ezio , Pagano Loredana

Introduction: The recurrence rate of intermediate-risk differentiated thyroid carcinoma (DTC) ranges between 5% and 20% and the therapeutic strategy requires further evaluations.Aim: We therefore investigated the potential risk factors for post-treatment recurrence of intermediate-risk DTC at 1 and 3 years from diagnosis.Methods: This retrospective observational study included 121 patients who underwent thyroidectomy for intermedia...

ea0035p145 | Calcium and Vitamin D metabolism | ECE2014

The association between vitamin D deficiency and metabolic parameters in pediatric obesity is influenced by what surrogate index of sunlight exposure is used

Prodam Flavia , Zanetta Sara , Bellone Simonetta , Ricotti Roberta , Giglione Enza , Marolda Agostina , Petri Antonella , Zavattaro Marco , Aimaretti Gianluca , Bona Gianni

Introduction: The association between vitamin D (25(OH)D) levels and metabolic parameters is not confirmed in some population studies. 25(OH)D concentration in blood is influenced by seasons and this covariate may explain some discordant results. The first aim of our study was to evaluate the prevalence of 25(OH)D deficiency in a population of obesity children (2–18 years) living in the North of Italy (latitude, 45°27′n) with respect to the season. The...

ea0032p467 | Diabetes | ECE2013

Efficacy and safety of 1 year treatment with Liraglutide in subjects with type 2 diabetes

Prodam Flavia , Zavattaro Marco , Ponziani Chantal , Pagano Loredana , Caputo Marina , Allochis Gabriele , Teresa Sama Maria , Busti Arianna , Aimaretti Gianluca

Introduction: Liraglutide, a GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the efficacy and safety of liraglutide in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). All patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatment, or patients intole...