Searchable abstracts of presentations at key conferences in endocrinology

ea0036P55 | (1) | BSPED2014

Journey through setup of adolescent gender identity dysphoria service for Notheren Ireland

Abid Noina , Ajzensztejn Michal

We describe the development of a new adolescent gender identity dysphoria (GID) service in Northern Ireland (population 1.8 million). Historically patients with GID <18 years were referred to The London joint Tavistock UCH adolescent GID service on a case by case basis. Following the commissioning of a GID service in Northern Ireland, a team of clinical psychologists, paediatric endocrinology nurse specialists, psychiatrist and paediatric endocrinologists, the first GID cl...

ea0058p058 | Diabetes | BSPED2018

Can Download Clinics’ improve diabetes metabolic control?

Gomes Sonia , Ajzensztejn Michal

Introduction: Optimal care in Type 1 Diabetes (T1DM) requires intensive insulin management with regular dose adjustments. A Download clinic (DC) was created for all patients attending the Paediatric Diabetes clinic. Patients downloaded their glucometers, pumps and Continuous Glucose Monitors (CGM) either at home or hospital. After analysis, the diabetes team provided feedback by email and phone.Objectives: To analyse the effects of the DC on the metaboli...

ea0066p55 | Diabetes 5 | BSPED2019

Iatrogenic cardiac arrest and severe neurological complications in DKA (diabetic ketoacidodis)

Ghauri Rooha Ijaz , Ajzensztejn Michal , Patankar Chhaya

Cardiac complications including cardiac arrest in Diabetic Ketoacidosis (DKA) have been reported in adults but is not common in children. We present a case of a 3½ year old child with new onset Type 1 Diabetes who presented in severe DKA and went into cardiac arrest needing prolonged resuscitation after starting insulin infusion due to rapid drop of serum potassium (K+). Serum K+ on presentation was 2.8 mmol/l and dropped to 1.5 mmol/l within 2.5 h of starting insulin lea...

ea0051p004 | Thyroid | BSPED2017

Double Trouble in a case of iatrogenic induced hyperthyroidism

Appleby Gayle , Lascelles Karine , Arya Ved , Ajzensztejn Michal

Background: Twin sisters with infantile epilepsy developed biochemical hyperthyroidism after commencing Topiramate, which resolved post cessation. This case-report describes the events and has found limited evidence in the literature.Case presentation: MCDA twins, 9 months of age, were admitted with seizure activity. Additionally twin 2, had neurocutaneous melanosis and a viral respiratory illness. Medications on admission were: Levetiracetam, Vigabatrin...

ea0085p31 | Miscellaneous 1 | BSPED2022

Clinical features of multiple endocrine neoplasia type 1 in children

Oprea Alina , Izatt Louise , Ajzensztejn Michal , Carroll Paul , Wei Christina

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominantly inherited condition predisposing to primary hyperparathyroidism (PHPT), pituitary tumors, gastroenteropancreatic tract neuroendocrine tumors (NET), thymic tumours and skin lesions. Clinical features are rare in the paediatric population and guidance exists on the screening for complications of MEN1.Objective: To describe clinical features and treatment outcomes in a sin...

ea0058p042 | Thyroid | BSPED2018

Impact of iodine deficiency on thyroid function in vegan siblings

Brandt Agnieszka , Ajzensztejn Michal , Sakka Sophia , Cheung Moira , Hulse Tony

Background: Iodine deficiency is the most common cause of acquired hypothyroidism worldwide. Incidence of iodine deficiency may be rising due to usage of vegan diet.Case presentation: We present siblings aged 2.5 years boy and 6 years old girl from family who are strict vegans. Both children have been on vegan diet since birth. Boy attended hospital urgently due to significant concerns about hypothyroidism. His TSH level 2 months before admission was 187...

ea0051p043 | Pituitary and growth | BSPED2017

SOX3 gene duplication (OMIM 313430) associated with midline CNS malformations, hypopituitarism and neurodevelopmental abnormalities: 3 unrelated cases

Nambisan Aparna K.R. , Kapoor Ritika , Ajzensztejn Michal , Hulse Tony , Buchanan Charles R.

Introduction: Duplications of the SOX3 gene at Xq27.1 are known to be associated with a spectrum of forebrain midline defects, isolated or multiple pituitary hormone deficiencies, spina bifida and sometimes learning difficulties. We report three cases of SOX3 duplication with hypopituitarism and differing presentations.Case reports: 1) A male infant presented in neonatal period with poor feeding, prolonged jaundice, central hypothyroidism and inadequate ...

ea0036P28 | (1) | BSPED2014

Diabetes A&E attendances and ward admissions pre and post implementation of an out of hours telephone service

Lillitos Peter , Ihe Chibuzor , Ramaswamy Priya , Ajzensztejn Michal , Chapman Simon , Lawrence Joanna , Begum Halima

Introduction: Daytime support from the diabetes-team reduces pressure on acute services however out-of-hours less support exists and diabetes related attendances to A&E are a potentially avoidable burden on resources. With the introduction of paediatric diabetes best-practice-tariff, recommendations included 24 h access to trained diabetes professionals for patients with known diabetes. In 2013 our three institutions created a consultant led out-of-hours paediatric diabete...

ea0058p054 | Diabetes | BSPED2018

Network-wide audit of ‘hypo supplies’ availability in children and adolescents with type 1 diabetes mellitus – interim results

Kanumakala Shankar , Ajzensztejn Michal , Jones Christina , Veleshala Sereesha , Parkash Usha , Hulse Tony

Introduction: Hypoglycaemic episodes (Hypos) can happen at any time in type 1 diabetes patients; sometimes quite unpredictably. Carrying ‘hypo supplies’ at all times is basic to good diabetes care; often delegated to parents for children with diabetes. The primary aim was to assess how this basic care activity is practised in real life; secondary aim was to correlate lack of hypo supplies with diabetes control or other patient characteristics.M...

ea0030oc2.1 | Oral Communications 2 | BSPED2012

Assessment of adrenal function in female to male adolescents with gender identity dysphoria

Ajzensztejn Michal , Gopalakrishnamoorthy Mahalakshmi , Dawnay Anne , Viner Russell , Brain Caroline , Butler Gary

Introduction: Most adolescents with GID have no overt functional or phenotypic abnormalities to explain their presentation. Currently all female to male (FtM) persons undergo detailed evaluation of adrenal function. This study aimed to determine whether subtle abnormalities of adrenal were present and what the appropriate investigation schedule should be.Methods: Over the past 4 years, 55 biological females aged mean age 16.54 years (13.46–18.37) we...