Searchable abstracts of presentations at key conferences in endocrinology

ea0030oc1.7 | Oral Communications 1 | BSPED2012

Novel therapies herald novel diseases: The first paediatric case series of Graves' immune reconstitution disease

Sinha Akash , Abinun Mario , Cheetham Tim

Introduction: The use of haematopoietic stem cell transplantation (HSCT) as a curative therapy for life threatening immunodeficiency signalled a paradigm shift in clinical outcomes. However, a subset of patients may experience Thyroid Immune Reconstitution Inflammatory Syndrome (IRIS) following immune reconstitution. This is recognised in the adult population but has received little attention in the paediatric literature. We present, what we believe to be, the first case serie...

ea0017p53 | (1) | BSPED2008

Social factors and glycaemic control in children with type 1 diabetes mellitus

Sinha Akash , Cassans Rebecca , Kibirige Mohammed

Aims: To determine whether single parenthood, special needs, ethnicity and indices of multiple deprivation 2007(proxy for social deprivation) influence metabolic control in T1DM.Methodology: Retrospective study (12 months) from 01/01/2007 till 31/12/2007. Data on several demographic and clinical variables were obtained from 105 children with T1DM from a single centre, after applying explicit exclusion criteria. Glycaemic control was assessed using HbA1c ...

ea0031oc1.6 | Young Endocrinologists prize session | SFEBES2013

Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle

Sinha Akash , Hollingsworth Kieren , Ball Steve , Cheetham Tim

Objective: Suboptimal mitochondrial function has been implicated in several disorders where fatigue is a prominent feature. Vitamin D deficiency is a well-recognised cause of fatigue and myopathy. The aim of this study was to examine the effects of cholecalciferol therapy on skeletal mitochondrial oxidative function in symptomatic, vitamin D deficient individuals.Design: This longitudinal study assessed mitochondrial oxidative phosphorylation in the gast...

ea0031p253 | Pituitary | SFEBES2013

In vivo characterisation of skeletal muscle metabolism in GH deficient adults using phosphorus-31 magnetic resonance spectroscopy

Sinha Akash , Hollingsworth Kieren , Ball Steve , Cheetham Tim

Context: GH deficient (GHD) adults can experience fatigue which resolves with GH replacement. The precise basis of this is unclear. Suboptimal mitochondrial function has been demonstrated in several conditions in which fatigue is a prominent symptom. Phosphorus-31 magnetic resonance spectroscopy (31P-MRS) can measure maximal mitochondrial oxidative phosphorylation, an important parameter of mitochondrial function. We have adapted this technique to enable non-invasive measureme...

ea0031p265 | Pituitary | SFEBES2013

Examining the distribution of abdominal fat in GH deficiency using magnetic resonance imaging

Sinha Akash , Hollingsworth Kieren , Ball Steve , Cheetham Tim

Background: Adults with GH deficiency (GHD) have altered body composition with an increase in abdominal fat when compared with healthy matched controls. However, most studies have not compared GHD adults with GHD adults on GH replacement.Abdominal fat is composed of subcutaneous abdominal tissue (SAT) and visceral abdominal tissue (VAT). Increased VAT is associated with poor metabolic outcomes. Magnetic Resonance Imaging (MRI) is a reliable and reproduci...

ea0030oc2.3 | Oral Communications 2 | BSPED2012

Does vitamin D modulate mitochondrial oxidative phosphorylation?

Sinha Akash , Ball Steve , Hollingsworth Kieren , Cheetham Tim

Introduction: Mitochondria are critical organelles which generate most of the energy (ATP) in the eukaryotic cell by oxidative phosphorylation. Impaired mitochondrial function will, therefore, restrict myocellular function. Vitamin D deficiency is widely prevalent with fatigue amongst its commonest manifestation. 31P-MRS is a non-invasive technique used to measure skeletal muscle bioenergetics in vivo. We have examined the relationship between vitamin D and mitochon...

ea0030p9 | (1) | BSPED2012

Vitamin D trending: trends in vitamin D status, measurement and prescribing in Northern England, 2002–2011

Baggott Lucy , Pattman Stewart , Cheetham Tim , Sinha Akash

Introduction: The vitamin D (25OHD) status of a population will reflect genetic and environmental factors. We evaluated all 25OHD assays undertaken at a regional centre in an area at high risk of vitamin D deficiency, over a 10 year period on the basis that this would provide insight into annual, seasonal and age based trends in 25OHD status. We planned to correlate vitamin D measurement with trends in vitamin D prescribing.Methods: Data (66 694 samples)...

ea0030p49 | (1) | BSPED2012

Mind over muscle: investigating the biology of fatigue in GH deficiency using 31P-MRS

Sinha Akash , Hollingsworth Kieren , Ball Steve , Cheetham Tim

Introduction: Even though fatigue is a common complaint in GH deficiency (GHD), its pathophysiology remains poorly understood. Fatigue can reflect central or peripheral disease processes. 31-Phosphorus magnetic resonance spectroscopy (31P-MRS) is a non-invasive technique used to measure skeletal muscle bioenergetics in vivo. Specifically, mitochondrial oxidative phosphorylation and proton efflux can be measured dynamically and in ‘real time’. The ai...