Searchable abstracts of presentations at key conferences in endocrinology

ea0044p30 | Adrenal and Steroids | SFEBES2016

Suppression of 11β-hydroxysteroid dehydrogenase type 1 target gene regulation by hypoxia

Shammout Bushra , Alase Adewonuola , Wittmann Miriam , Stewart Paul , Tiganescu Ana

Delayed wound healing (WH), characterized by ischemia, is exacerbated by glucocorticoid (GC) excess. Local GC availability is regulated by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which generates the GC cortisol from inactive cortisone. We previously reported improved WH in 11β-HSD1-null mice but regulation of 11β-HSD1 by hypoxia in human skin remains unknown. Primary human dermal fibroblasts (HDF, biological n=3), were treated...

ea0044p35 | Adrenal and Steroids | SFEBES2016

11β-hydroxysteroid dehydrogenase type 1 mediates anti-inflammatory, pro-inflammatory and inflammation-independent effects in primary human dermal fibroblasts

Farraj Layal Abi , Morgan Michael , Alase Adewonuola , Carr Ian , Stewart Paul , Tiganescu Ana

Glucocorticoids (GC) drive multiple adverse effects in skin e.g. epidermal thinning, dermal atrophy and impaired wound healing (WH). Our previous findings indicate increased expression of the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in primary human dermal fibroblasts (HDF), full-thickness skin from older donors and during the inflammatory phase of mouse skin WH. We also reported protection from age-induced dermal atrophy and improved W...