Searchable abstracts of presentations at key conferences in endocrinology

ea0024bc1.1 | (1) | BSPED2010

Investigation of premature adrenarche reveals a high incidence of congenital adrenal hyperplasia (CAH)

Kosta K , Gkourogianni A , Alatzoglou K S , Hindmarsh P C , Dattani M T

Background: Premature pubic hair development, with or without manifestations of androgen production, is a common clinical presentation. Premature adrenarche (PA) needs to be differentially diagnosed from congenital adrenal hyperplasia (CAH) and may be associated with early development of puberty.Aim: To study the characteristics at presentation, endocrine profile and outcome of patients who presented with premature pubic hair development. We studied retr...

ea0024p19 | (1) | BSPED2010

Outcome of rhGH treatment in patients with achondroplasia and skeletal dysplasias

Alatzoglou K S , Mohan R , Ward S , Bridges N , Brook C G D , Hindmarsh P C , Dattani M T

Background and aim: Achondroplasia (ACH) is one of the commonest skeletal dysplasias affecting 1:15 000–1:40 000 live births. The average attained adult height is 131±5.6 cm for men and 124±5.9 cm for women. Previous studies have shown that the use of rhGH may result in transient increase in the growth rate, but there have been no long-term data regarding adult height. We aimed to study a cohort of patients with ACH and other skeletal dysplasias who have been tr...

ea0024oc2.7 | Oral Communications 2 (Brief Communications) | BSPED2010

Wide range of eye abnormalities in patients with hypopituitarism: is this showing a novel genetic aetiology?

Alatzoglou K S , Kelberman D , Spadoni E , Gaston-Massuet C , Woods K , Natarajan A , Maghnie M , Bitner-Glinzicz M , Dattani M T

Background and Aim: The development of the pituitary gland is closely linked to this of the eyes and forebrain, as they all originate from the same embryonic origin, the anterior neural ridge. The constellation of symptoms leading to septo-optic dysplasia (SOD) is well established; other ophthalmic signs may be under-reported. The aim of the study was to define if patients with hypopituitarism present with eye abnormalities, which are distinct from optic nerve hypoplasia (ONH)...