Searchable abstracts of presentations at key conferences in endocrinology

ea0056p90 | Clinical case reports - Pituitary/Adrenal | ECE2018

Opioid-induced secondary adrenal insufficiency

Petre Oana Alexandra , Albu Alice

Introduction: Opioids are commonly used for the treatment of pain, and their effects on the HPA (hypothalamic pituitary adrenal) axis may be under-recognised. In the present, a few non-systematic studies have investigated the effects of opioids on the HPA axis, but results have been conflicting. To our knowledge, there is only another case report of secondary adrenal insufficiency due to tramadol therapy, resulted in suppression on the HPA axis. We present the case of a 79 yea...

ea0037ep213 | Reproduction, endocrine disruptors and signalling | ECE2015

The impact of adiposity on serum anti-Mullerian hormone in normal and overweight women with decreased ovarian reserve

Albu Dragos , Tulin Raluca , Albu Alice

Background: Few previous studies suggested a negative impact of obesity on anti-Mullerian hormone (AMH) serum levels in patients with decreased ovarian reserve, but the data regarding the relationship between AMH and adiposity in the same category of patients without severe excess of body weight are scarce.Aim: The aim of the study was to evaluate the relationship between AMH serum levels and BMI in normal weight and overweight patients with reduced ovar...

ea0073aep487 | Pituitary and Neuroendocrinology | ECE2021

Case report: Girl with short stature with no response to growth hormone treatment

Teodora Gheorghe Elena , Ioana Albu Alice

IntroductionGrowth hormone deficiency (GHD) is a rare disorder and severe forms of GHD may have a genetic basis. Familial isolated growth hormone deficiency (IGHD) is classified into 4 types, type IA being the most severe form. These patients present with severe growth failure with undetectable growth hormone (GH) concentrations and about 50% tend to develop antibodies on GH treatment.(1, 2, 3) The appearance of anti-GH antibodies may not be a regular fi...

ea0073aep755 | Thyroid | ECE2021

Is there a link between the levels of vitamin D and differentiated thyroid cancer risk in multinodular goiter patients?

Tudorache Alina , Albu Alice , Scarabnii Tatiana

IntroductionBoth vitamin D insufficiency and multinodular goiter (MNG) are widespread throughout the world, with Romanian population being no exception. However, at this point in time there is insufficient data whether there is a connection between the two or is it just a coincidence. The aim of this study is to evaluate whether there is a relationship between serum level of 25-hydroxyvitamin D (25OHD) and the risk of differentiated thyroid cancer (DTC) ...

ea0049ep307 | Calcium & Vitamin D metabolism | ECE2017

Risk factors associated with osteoporosis in beta-thalassaemia major patients

Iancu Elena Mirela , Albu Alice Ioana , Nicolaescu Irina

Beta-thalssaemia major (BTM) is a rare disease that encompasses a vast range of endocrinological complications, despite of the improvement of treatment protocols. The aim of this study was to identify the clinical and hematological parameters associated with osteoporosis, a frequent complication found in beta-thalassaemia patients.Patients with BTM were evaluated in the Endocrinology Department of Elias Hospital between February 2004 and March 2016. Only...

ea0049ep1147 | Female Reproduction | ECE2017

The determinants of thyroid autoimmunity in patients with polycystic ovary syndrome

Albu Alice , Petre Oana , Nicolaescu Irina , Gheorghe Ivona , Albu Dragos

It was suggested that polycystic ovary syndrome (PCOS) patients have an increased risk for autoimmune thyroid disease. However the mechanisms underlying this association are incompletely clarified. The aim of the present study is to evaluate the factors associated with thyroid autoimmunity in patients with PCOS. We performed a retrospective study which included 126 PCOS patients (mean age 24±4.5 years, mean body mass index, BMI 27±7.33 kg/sqm) diagnosed based on Rott...

ea0037ep123 | Steroids, development and paediatric endocrinology | ECE2015

Is there a link between lipid profile and thyroid function modification during somatropinum treatment for GH deficiency in children?

Stejereanu Lavinia , Cima Luminita , Albu Alice , Barbu Carmen , Fica Simona

Background: Previous studies suggested that treatment with somatropinum in children with GH deficiency (GHD) may alter lipid profile and pituitary–thyroid axis function. However, results are divergent and data regarding a possible association between changes of thyroid function and of circulating lipids are scarce. The aim of this study was to report the changes of the lipid profile in children with GHD treated with somatropinum and the relationship between thyroid functi...

ea0037ep197 | Reproduction, endocrine disruptors and signalling | ECE2015

The connection between serum prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients

Albu Alice , Radian Serban , Florea Suzana , Fica Simona

Introduction: Both TSH and prolactin serum levels within normal range were previously reported to be associated with metabolic parameters.Aim: To analyse the connections between serum levels of prolactin, TSH, and insulin resistance in polycystic ovary syndrome patients.Material and methods: 322 PCOS patients (mean age 24.3±5.16 years and mean BMI 28±7.57 kg/m2) with normal serum prolactin and without thyroid d...

ea0090ep688 | Pituitary and Neuroendocrinology | ECE2023

The predictive value of IGF-1 in a cohort of children with growth hormone deficient and sufficient short stature

Maria Anton Ana , Cristina Georgescu Ioana , Tudorache Alina , Elena Teodora Gheorghe , Gabriela Barbu Carmen , Albu Alice

Introduction: Insulin-like growth factor 1 (IGF-1) is an established serum marker for both diagnosis of growth hormone (GH) deficiency and for monitoring treatment with Somatropin, whether it is recommended for the classic GH-insufficient short stature cases or for other GH-sufficient disorders.Aim: To evaluate whether serum level of IGF-1 at diagnosis has a predictive value for the response to somatropin treatment during the 2 years of treatment in chil...

ea0063p479 | Calcium and Bone 2 | ECE2019

Relationship between serum levels of 25-OH vitamin D and parameters of bone mineralization (BMD) and bone quality (TBS) in clinical practice

Sirbu Anca , Popa Miruna , Martin Sorina , Albu Alice , Barbu Carmen , Sava ELisabeta , Fica Simona

Introduction: Vitamin D is a hormone essential for calcium absorption and bone mineralization, which is positively associated with bone mineral density. The aim of our study was to evaluate the relationship between 25-OH vitamin D values and parameters of bone mineralization (bone mineral density - BMD) and bone quality (trabecular bone score - TBS) in patients from day to day clinical practice.Materials and methods: We evaluated 433 postmenopausal women...