Searchable abstracts of presentations at key conferences in endocrinology

ea0081p709 | Reproductive and Developmental Endocrinology | ECE2022

Serum testosterone mirrors inflammation parameteres in females admitted with covid-19 disease

Francesca Birtolo Maria , Vena Walter , Pizzocaro Alessandro , Jaafar Simona , Ciafardini Antea , Brunetti Alessandro , Pigni Stella , Mazziotti Gherardo , Lania Andrea

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is showing a rapid and continuous evolution in terms of new waves, the spread of variants and the evidence of reinfections. The growing heterogeneity of clinical presentation requires the identification of underlying pathogenic mechanisms to allow a better risk stratification. Previous studies analysed the role of sex hormones in disease severity demonstrating in male patients the association of...

ea0081ep594 | Endocrine-Related Cancer | ECE2022

New CDKN1b mutation in multiple endocrine neoplasia type 4 and brief literature review on clinical management.

Brunetti Alessandro , Lavezzi Elisabetta , Bertuzzi Alexia , Nappo Gennaro , Laffi Alice , Pedicini Vittorio , Vitali Eleonora , Trivellin Giampaolo , Mazziotti Gherardo , Lania Andrea

Background: The fourth type of Multiple Endocrine Neoplasia (MEN) is a rare variant of MEN presenting a MEN1-like phenotype and originating from a germline mutation in CDKN1B. However, due to the small number of cases documented in literature, the peculiar clinical features of MEN4 are still largely unknown, and clear indications about the clinical management of these patients are currently lacking. In order to enlarge our knowledge on MEN4 and to better typify the clinical fe...

ea0063p694 | Pituitary and Neuroendocrinology 2 | ECE2019

New markers of systemic inflammation and oxidative macromolecular damage in partial and total Adult Growth Hormone Deficiency

Bruno Carmine , Vergani Edoardo , Brunetti Alessandro , Guidi Francesco , Angelini Flavia , Meucci Elisabetta , Silvestrini Andrea , Basile Umberto , Mancini Antonio

It is known that adult growth hormone deficiency (GHD) is associated with oxidative stress (OS): both GH and IGF-1 exert antioxidant functions. OS is in turn related to systemic inflammation and cardiovascular/oncological risk. Discordant data concerning GH effects on antioxidants are reported. Moreover, no data are available in partial GHD, which can induce cardiovascular alterations. To evaluate oxidative damage on macromolecules and systemic inflammation, 80 patients, studi...

ea0056gp66 | Cardiovascular | ECE2018

Evaluation of irisin levels in chronic heart failure with preserved or reduced ejection fraction

Mancini Antonio , Silvestrini Andrea , Bruno Carmine , Vergani Edoardo , Brunetti Alessandro , Favuzzi Angela Maria Rita , Guidi Francesco , Meucci Elisabetta , Mordente Alvaro

Background: The recently discovered myokin Irisin, a peptide originated by a proteolytic cleavage of the transmembrane protein fibronectin type III domain containing 5 (FNDC5) whose expression is induced by exercise and/or by increasing peroxisome proliferator-activated receptor (PPAR)-γ co-activator 1α (PGC-1α), has been considered a prognostic factor in Chronic Ischemic Cardiomyopathy and Acute Heart Failure. Nevertheless, no data are available on Irisin level...

ea0101ps1-09-02 | Nodules | ETA2024

Acromegaly and thyroid nodules: a retrospective, single-centre, real-world observational study

Manso Jacopo , Brunetti Alessandro , Stefano Salcuni Antonio , Cellini Miriam , Cipri Claudia , Kara Elda , Purinan Alessandro , Carpentieri Maria , Vescini Fabio

Objectives: Acromegaly is a rare disease that can cause complications in multiple organs. Although excess IGF-1 may contribute to the development of thyroid nodules, the association between acromegaly and thyroid nodules is still a topic of debate, and the available data are limited and contradictory. The aim of this study was to investigate the potential influence of acromegaly and its treatment on thyroid nodules.Methods: This is a retrospective, singl...

ea0093oc16 | Oral communication 3: Adrenal Tumors and Neuroendocrine Tumors | EYES2023

Bone fragility in well-differentiated gastroenteropancreatic-neuroendocrine tumors: Results from a retrospective two-centered study

Brunetti Alessandro , Jaafar Simona , Chiardi Isabella , Cellini Miriam , Salcuni Antonio Stefano , Pigni Stella , Lavezzi Elisabetta , Lania Andrea , Mazziotti Gherardo , Vescini Fabio

Background: Patients affected by gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) present an increased risk of bone fragility due to several factors, such as bone metastases, vitamin D deficiency, hormonal secretion, medical and surgical treatments. Although patients with well-differentiated GEP-NETs generally present a long life-expectancy, occurrence of fragility fractures could significantly impair quality of life.Objectives: The study aims to ...

ea010268 | Reproductive Endocrinology | EYES2024

Anogenital distance in klinefelter syndrome: a case-control study

Vitale Valentina , Vena Walter , Bughetti Chiara , Brunetti Alessandro , Maida Giulia , Morenghi Emanuela , Negri Luciano , Benaglia Renzo , Bossi Antonio , Vescini Fabio , Mazziotti Gherardo , Lania Andrea , Pizzocaro Alessandro

Background: Serum testosterone (T) levels may fall at different stages of sexual development in Klinefelter syndrome (KS), whereas overt hypogonadism typically arises after puberty. Nevertheless, normal mini-puberty and puberty are still debated in KS subjects. Anogenital distance (AGD) is an anthropometric parameter under the influence of early life and childhood androgen exposure. Genital anomalies, testicular cancer and oligospermia have been associated with a shorter AGD i...

ea0081p305 | Calcium and Bone | ECE2022

Reliability of who fracture risk assessment tool (frax) and bone mineral density in predicting fractures in cancer patients under hormone deprivation therapies: a real-world clinical study

Vena Walter , Piccini Sara , Pedersini Rebecca , Carrone Flaminia , Cosentini Deborah , Zucali Paolo , Torrisi Rosalba , Brunetti Alessandro , Pigni Stella , Maroldi Roberto , Balzarini Luca , Lania Andrea Gerardo , Berruti Alfredo , Berruti Gherardo

Background: Skeletal fragility is an important clinical issue in women with early-stage breast cancer and men with non-metastatic prostate cancer under hormonal hormone deprivation therapies (HDTs). Vertebral fractures (VFs) have been reported in a remarkable number of subjects exposed to HDT especially when the diagnosis of fractures is performed by a radiological and morphometric approach. Notably, prediction of fractures in this clinical setting is a challenge and determina...

ea0081ep668 | Pituitary and Neuroendocrinology | ECE2022

A multicenter retrospective study on a large cohort of patients with primary empty sella: hormonal and neuroradiological features over a long follow-up

Carosi Giulia , Brunetti Alessandro , Mangone Alessandra , Baldelli Roberto , Tresoldi Alberto , Sindaco Giulia Del , Lavezzi Elisabetta , Sala Elisa , Mungari Roberta , Fatti Letizia Maria , Galazzi Elena , Ferrante Emanuele , Indirli Rita , Biamonte Emilia , Arosio Maura , Cozzi Renato , Gerardo Antonio Lania Andrea , Mazziotti Gherardo , Mantovani Giovanna

Background: primary empty sella (ES) represents a frequent finding (up to 35% of the general population). According to the literature, the prevalence of hypopituitarism in ES ranges between 19-52%. Data on the natural history of ES over a long time, especially in incidental ES, are still lacking and the management can be challenging.Objective: our primary aim was to assess in a large cohort of patients with ES the prevalence and determinants of hypopitui...