Searchable abstracts of presentations at key conferences in endocrinology

ea0099p223 | Adrenal and Cardiovascular Endocrinology | ECE2024

Medication-associated false positive results for plasma normetanephrine, metanephrine and methoxytyramine

Knigge Lara , Potthoff Kristin , Constantinescu Georgiana , Alessi Francesco , Fuld Sybille , Zawadzka Karolina , Bornstein Stefan , Lenders Jacques , Eisenhofer Graeme , Pamporaki Christina

Background: Measurements of plasma metanephrines provide a sensitive test for diagnosis of pheochromocytoma/paraganglioma (PPGL). However, false positive results can pose a diagnostic dilemma for clinicians. The aim of the study was to determine whether commonly prescribed drugs with potential action on the sympathetic nervous system can falsely elevate plasma free normetanephrine, metanephrine and methoxytyramine.Methods: This retrospective study includ...

ea0099p14 | Adrenal and Cardiovascular Endocrinology | ECE2024

Improved selectivity of adrenal venous sampling with the use of alternative steroids to cortisol

Alessi Francesco , Costantinescu Georgiana , Peitzsch Mirko , Remde Hanna , Kurzinger Lydia , Schulze Manuel , Lee Myron , Yang Jun , Reinke Martin , Beuschlein Felix , Bornstein Stefan , Lenders Jacques , Pamporaki Christina , Eisenhofer Graeme

Background: Current guidelines recommend adrenal vein sampling (AVS) for the identification of surgically treatable unilateral disease among patients with primary aldosteronism (PA). The cortisol-derived selectivity index (SI) is currently used to assess the success (or selectivity) of adrenal vein catheterization during AVS. However, AVS studies can be non-selective in many cases.Aim: To examine whether the use of SI derived either from 11-deoxycortisol...

ea0099p16 | Adrenal and Cardiovascular Endocrinology | ECE2024

False-positive and false-negative results during screening, confirmatory testing and subtyping for suspected primary aldosteronism: lessons from Prosaldo

Constantinescu Andreea Georgiana , Pamporaki Christina , Alessi Francesco , Passauer Jens , Remde Hanna , Kuerzinger Lydia , Fuss CarminaTeresa , Schulze Manuel , Peitzsch Mirko , Horvath Andrea , Yang Jun , Bruedgam Denise , Williams TracyAnn , Reincke Martin , Gruber Sven , Beuschlein Felix , Lenders Jacques , Eisenhofer Graeme

Background: Diagnostic stratification of patients with suspected primary aldosteronism (PA) is a multistep process reliant on tests that are not infallible. Only through prospective studies can diagnostic accuracy be appropriately assessed.Methods: The PROSALDO trial enrolled 819 patients between 2019 and 2023 to assess steroid profiles against routine tests for diagnostic stratification. A combination of these tests and outcome assessments, including me...

ea0099p236 | Adrenal and Cardiovascular Endocrinology | ECE2024

Impact of environmental pollution on adrenocortical carcinoma in Italy

Puglisi Soraya , Calabrese Anna , Ferrau Francesco , Alessi Ylenia , Lagana Marta , Grisanti Salvatore , Ceccato Filippo , Scaroni Carla , Di Dalmazi Guido , Stigliano Antonio , Altieri Barbara , Canu Letizia , Luconi Michaela , Loli Paola , DeMartino Maria Cristina , Arvat Emanuela , Palmieri Serena , Perotti Paola , Basile Vittoria , Berchialla Paola , Berruti Alfredo , Pia Anna , Reimondo Giuseppe , Cannavo Salvatore , Terzolo Massimo

Background: Whether environmental pollution may influence adrenocortical carcinoma (ACC) development remains largely unknown. The aim of this study was to evaluate the impact of exposition to environmental pollutants on ACC presentation and prognosis in Italy.Patients and methods: A retrospective analysis was done on 500 patients affected by ACC, who were diagnosed in 12 reference centers in Italy from 1990 to 2018 and followed-up for a median of 37.5 mo...