Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1141 | Female Reproduction | ECE2017

Epigenetics of female hypogonadotropic hypogonadism: analysis of mRNA expression of engaged in IHH genes

Loktionova Anna , Ilovayskaya Irena , Eneva Natela , Khusniyarova Karina , Nefedova Lidia , Kim Alexander , Dreval Alexander

Hypogonadotropic hypogonadism is a syndrome which may be manifested clinically by low sex steroids because of low (or inappropriately normal) gonadotropins. To date, more than 30 genes were reported as possible reason for this condition, but genetic basis is still unknown for ~60% of HH cases. Due to this fact we decided to analyze mRNA expression of several HH-related genes which can be found in leukocytes of peripheral blood: GNRHR and GNRH1 (which are necessary for adequate...

ea0022p656 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Diabetes Mellitus influence on GH and IGF-1 levels in acromegalic patients

Alexander Dreval , Irina Trigolosova

Background: Diabetes mellitus is one of the serious acromegaly complication.As well known, glycemia influences growth hormone (GH) secretion. From this point of view, it is interesting to investigate feature peculiarity of GH and Insulin like Growth Factor 1 (IFG-1) secretion when acromegaly is coupled with diabetes mellitus.Aim: Of this study was to investigate diabetes mellitus influence on GH and IGF-1 levels in acromegalic pati...

ea0035p239 | Clinical case reports Pituitary/Adrenal | ECE2014

Clinical case of pituitary apoplexy due to hemorrhagic vasculitis

Dreval Alexander , Shestakova Tatiana , Komerdus Irina

Introduction: Pituitary apoplexy is the rare case of panhypopituitarism. We are presenting a clinical case of pituitary apoplexy in a previously healthy 37-year-old woman.Case report: A 37-year-old woman developed amenorrhea in August 2011. She did not visit a doctor in that time. In December 2011 she suddenly felt severe headache, symptoms of polyuria and polydipsia and temperature of 39 °C. Laboratory results revealed an increased erythrocyte sedi...

ea0032p283 | Clinical case reports - Thyroid / Others | ECE2013

A case of generalized resistance to thyroid hormone with chronic thyroiditis

Shestakova Tatiana , Dreval Alexander , Komerdus Irina

Introduction: Resistance to thyroid hormone (RTH) is a rare disorder characterized by reduced tissues’s responsiveness to thyroid hormones (TH). Usually patients with RTH have not clinical signs except goiter. We describe a 70-years old woman with RTH and autoimmune thyroiditis simultaneously.Case report: Woman 70-years old was hospitalized in our department on August 2011 with suspicious of Thyrotropinoma because of high levels of TSH and fT4<...

ea0020p150 | Thyroid | ECE2009

Fever in the debute of the diffuse toxic goiter

Kamynina Tamara , Gubkina Valeria , Dreval Alexander

Aim: To pay attention to the so rare symptom of diffuse toxic goiter (DTG) as fever.Materials and methods: We report about 5 patients (all females, aged 18–38, mean – 31). Before, all patients were examined for fever of unknown origin of long duration. After the others reasons of the febrile body temperature were excluded, DTG was diagnosed. DTG was confirmed by the results of the clinical, hormonal and immunological investigations (T- and B-ce...

ea0020p175 | Endocrine tumours and neoplasia | ECE2009

Pregnancy and childbirth in active acromegaly patient treated with long acting somatostatin analog

Nechaeva Olga , Pokramovich Julia , Dreval Alexander

In 24 years old woman in March 2007 was diagnosed acromegaly (somatoprolactinoma) an active phase, hyperprolactinemia. Manifestations: rugged features, amenorrhea, galactorrhea, fasting GH – 144 ng/ml (N<10 ng/ml), IGF-1 – 586 ng/ml (N 48–450 ng/ml), PRL – 6726 mU/l (N 40–530 mU/l). According to pituitary MRT a tumor volume was 14.4 cm3, with supra- and infrasella growth. She was operated in May 2007: transnal transs...

ea0049ep905 | Neuroendocrinology | ECE2017

MR-characteristics as predictors of pituitary adenomas hormonal and proliferal activity

Krivosheeva Yulya , Dreval Alexander , Panteleeva Evgenia , Stashuk Galina , Ilovayskaya Irena

Introduction: Previous studies demonstrated a relationship between T1- and T2-weighted signal intensity and tumor growth pattern in pituitary somatotropinomas. The goal of this retrospective study was to analyze the MRI characteristics of pituitary macroadenomas with different hormonal activity in newly diagnosed patients.Material and methods: Pre-treatment T1- and T2-weighted MR-images (Intera Achieva, PHILIPS, 3.0T) of patients with 42 non-functional a...

ea0041ep34 | Adrenal cortex (to include Cushing's) | ECE2016

Menstrual function in women with cushing’s disease (CD)

Komerdus Irina , Akulkina Larisa , Chekanova Anastasiia , Dreval Alexander

Background: Menstrual abnormalities (MA) can be the first sign of the disease.Aim: To assess the structure of MA before and after treatment of CD.Material and methods: Twenty-eight women with CD 39 (31.8;43.5) y.o., were investigated initially and 3.5 (2;5.5) years after treatment. Patients were subdivided into three groups: with normal cycles (NC; 26–30 days), oligomenorrhea (31–120 days), amenorrhea (>120 days)....

ea0041ep918 | Pituitary - Clinical | ECE2016

Clinical proofs for necessity of macroprolactinemia screening

Ilovayskaya Irena , Dreval Alexander , Krivosheeva Yulia , Osipova Tatiana

Prevalence of macroprolactin in serum (>40%) can be a cause of asymptomatic hyperprolactinemia. However, there is still lack of evidence how to manage with symptomatic patients with macroprolactinemia.We analyzed clinical data and monomeric prolactin levels in 85 women of reproductive age with hyperprolactinemia: NonTumor hyperprolactinemia (NT, n=31), MIcroadenomas (MI, n=32), MAcroadenomas (MA, n=22). Prolactin levels 171...

ea0041ep922 | Pituitary - Clinical | ECE2016

Clinical characteristics of giant pituitary adenomas

Ilovayskaya Irena , Dreval Alexander , Krivosheeva Yulia , Stashuk Galina

Our Pituitary Tumour Registry includes data about 346 patients with pituitary macroadenomas: 142 non-functional adenomas (NFA) including 18 (12.7%) giant, 62 macroprolactinomas – 6 (9.7%) giant, 141 somatotropinomas – 6 (4.3%) giant. We analysed clinical features of these 30 giant pituitary tumors (<40 mm at least one of the sizes): 18 NFA (11 Females; 7 Males), 6 prolactinomas (3 Females; 3 Males), 6 somatotropinomas (3 Females; 3 Males). Patients with giant NFA...