Endocrine Abstracts

Carcinoma of the thyroid gland is an uncommon cancer but is the most common malignancy of the endocrine system. The treatment of the thyroid cancer includes surgery, radioactive iodine and hormone treatment. Postoperative hypothyroidism is the most common complication of thyroidectomy for thyroid cancer. After thyroidectomy, the patient takes a thyroid hormone drug (levothyroxine) in supresive dose for the rest of his life.In hypothyroidism there has bee...

Background: Prevalence and type of amiodarone-induced thyroid dysfunction in a population depend on geographical iodine intake.Aims: To assess differences in amiodarone-induced thyrotoxicosis pattern before and after iodine supplementation.Patients and methods: 84 patients (41M/43F) with amiodarone-induced thyrotoxicosis, aged 60.1±11.9 years, were retrospectively reviewed. 28 patients were resident in former iodine-deficient ...

Introduction: Struma ovarii is a rare condition which elicited considerable interest because of its many unique features like its relationship to teratoma and differentiated thyroid cancer. The most common thyroid carcinomas to arise in struma ovarii are papillary and follicular.Objectives: We describe two patients with differentiated thyroid carcinoma originating from malignant struma ovarii.Results: Our index patient is a 32-year...

Background: Low-serum concentrations of 25(OH)-vitamin D are associated with insulin resistance in adults. Recent in vitro studies have suggested that vitamin D may play a role in the regulation of adiponectin, leptin and resistin; since all these adipokines are related to insulin sensitivity modulation, they might represent a link between vitamin D status and insulin resistance.Aim: To identify possible correlations between 25(OH)-vitamin D ser...

Because of the increased prevalence of thyroid disorders in Romania we realized a retrospective study in which we followed the variance of TSH, function of temperature, in different seasons. In this context, based on TSH value we appreciated the need of thyroid hormones and antithyroid drugs to maintain an euthyroid state.Material and methods: The group of study consist of 634 patients, men and women over 18-years-old with thyroid disorders: hypo, hyper,...

Introduction: Hashimoto’s Thyroiditis is a part of the spectrum of thyroid autoimmune diseases. Even the proper diagnosis is obtained by pathological exam; usually the detection of high serum antithyroid antibodies is enough to diagnose the disorder. It also represents the most frequent cause of hypothyroidism in non-iodine deficient areas. Nevertheless the presence of the antithyroid antibodies does not always correlates with thyroid dysfunction.Ai...

Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are both autoimmune thyroid diseases. While transition from GD to hypothyroidism has been more frequently reported, conversion of hypothyroidism to GD is uncommon. We describe a series of 3 patients diagnosed with HT and hypothyroidism, treated with L-thyroxine (LT4), who developed persistent hyperthyroidism with increased thyrotropin receptor antibodies (TRAb) levels and, in two of the patients, Graves’ opht...

Introduction: Differentiated thyroid carcinoma is a rare entity in pediatric population, with particularities in diagnosis, management and outcomes.Methods, aim: Retrospective noninterventional study describing clinical presentation and outcomes of children with DTC.Results: Between 2011 and 2017 54 children and adolescents aged 7.8–18 years (mean age at diagnoses 14.4 years) with DTC were diagnosed/followed up in our Institut...

Background: Obesity is associated with adipocyte dysfunction, characterized by an impaired secretion of adipokines, which leads to a systemic inflammatory status.Aim: To characterize adipokines’ profile in a group of obese children and adolescents.Method: A case–control study comparing 102 obese children (BMI ≥95th percentile; aged 10–18 years) to a group of 43 healthy controls matched for age and pubertal stat...

Background: Oral glucose tolerance test (OGTT) is a step in the evaluation of children and adolescents with tall stature for documenting a possible autonomous GH secretion.Aim: Assessment of GH dynamics in OGTT in children and adolescents with tall stature in various stages of pubertal development for documenting a possible autonomous GH secretion.Method: Our study included 44 subjects, 18 girls and 26 boys, with age between 6.5 an...