ea0081rc12.1 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022
Jawich Kenda
, Santa Rocca Maria
, Al Fahoum Sahar
, Alhalabi Marwan
, Di Nisio Andrea
, Foresta Carlo
, Ferlin Alberto
, De Toni Luca
Purpose: Undercarboxylated-OCN (ucOCN), acting on the receptor GPRC6A, was shown to stimulate of testosterone (T) production in Leydig cells in rodents, in parallel with the hypothalamus/pituitary/gonadal axis mediated by luteinizing hormone (LH). Hence, reduced serum ucOCN and/or inactivating gene variants of GPRC6A, are supposed to affect testis function in humans. The aim of this study is to evaluate the association among serum ucOCN, rs2247911 GPRC6A gene polymorphism and ...