Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps3-13-122 | Pregnancy & Iodine | ETA2022

Preconception tsh levels and early gestation maternal thyroid function in a large cohort of women with hashimoto’s thyroiditis (ht) diagnosed preconceptionally

Moleti Mariacarla , Di Mauro Maria , Paola Giuseppe , Perdichizzi Laura , Ragonese Marta , Granese Roberta , Alibrandi Angela , Vermiglio Francesco

Several lines of evidence indicate an increased risk of adverse gestational outcomes in women with Hashimoto’s thyroiditis (HT) already as of TSH levels at early pregnancy >2.5mU/l, and definitely greater for TSH concentration >4mU/l. The latest guidelines recommend preconception TSH levels (pre-C-TSH) in HT women be maintained below 2.5mU/l, this threshold being expected to prevent hypothyroidism occurrence at early gestation.Objectives: To...

ea0049gp208 | Thyroid 2 | ECE2017

Serum Interleukin-37 (IL-37) levels were increased and correlated with oxidative stress parameters in Hashimoto’s Thyroiditis (HT) patients

Ruggeri Rosaria Maddalena , Vicchio Teresa Manuela , Alibrandi Angela , Giovinazzo Salvatore , Certo Rosaria , Giuffrida Giuseppe , Trimarchi Francesco , Gangemi Sebastiano , Cristani Mariateresa

Background: IL-37, member of the IL-1 family, is a natural suppressor of immune and inflammatory responses. Increased serum IL-37 levels were observed in several autoimmune diseases, including Graves’ disease. No data on TH are available from the literature.Materials and methods: We enrolled 45 euthyroid HT patients (5 M e 40 F, mean age 38.5±12.6) and 50 age- and sex-matched healthy controls. None was on LT-4 therapy. Smokers, subjects with ki...

ea0070aep870 | Thyroid | ECE2020

Dietary pattern and oxidative stress markers in hashimoto’s thyroiditis

Ruggeri Rosaria , Giovinazzo Salvo , Giuffrida Giuseppe , Teresa Vicchio Maria , Teresa Cristani Maria , Alibrandi Angela , Campenni Alfredo , Trimarchi University of Messina Francesco

Objective: Oxidative stress has been implicated in the pathogenesis of several immune-mediated disorders, including autoimmune thyroid disease. Aim of our study was to investigate the relationship between dietary habit and redox homeostasis, in relationship with thyroid autoimmunity.Materials and methods: We enrolled 200 healthy subjects (173 F, mean age 35 ± 12). None of them was under any pharmacological treatment. Exclusion criteria: any infectio...

ea0049gp175 | Pituitary | ECE2017

Resistance to somatostatin analogues is associated with GSTP1 gene methylation and AHR rs2066853 variant in acromegaly patients

Ferrau Francesco , Romeo Petronilla Daniela , Puglisi Soraya , Ragonese Marta , Spagnolo Federica , Ientile Riccardo , Picerno Isa Anna Maria , Curro Monica , Visalli Giuseppa , Alibrandi Angela , Cannavo Salvatore

Evidences suggest that environmental contaminants exposure and/or the impairment of intracellular xenobiotic metabolizing system could affect pituitary pathophysiology. Glutathione-S-transferase-P1 (GSTP1) gene encodes for an enzyme that is involved in cellular detoxification mechanisms. GSTP1 altered activity or expression has been reported in some tumours.We aimed to assess the GSTP1 gene promoter methylation status in acromegaly patients and its contr...

ea0049ep1056 | Pituitary - Clinical | ECE2017

Effects of pasireotide treatment on cardio-metabolic risk in patients with Cushing’s disease: an Italian, multicenter study

Albani Adriana , Ferrau Francesco , Messina Erika , Pivonello Rosario , Scaroni Carla , Giordano Carla , Cozzolino Alessia , Zilio Marialuisa , Guarnotta Valentina , Ciresi Alessandro , Iacuaniello Davide , Alibrandi Angela , Colao Annamaria , Cannavo Salvatore

: Patients with Cushing’s disease (CD) have increased cardiovascular risk due to metabolic alterations caused by glucocorticoids excess. Pasireotide, a multireceptor-targeted somatostatin analogue, is a therapeutic option in CD patients in whom surgery is not curative or not feasible. Pasireotide has been shown to be effective in controlling hypercortisolism and to improve metabolic features. Recently, the visceral adiposity index (VAI) has been proposed as a marker of vi...

ea0049ep1118 | Female Reproduction | ECE2017

Influence of peroxisome proliferator-activated receptor (PPAR)-γ exon 2 (Pro12Ala) and exon 6 (His447His) and Gly972Arg insulin receptor substrate (IRS)-1 polymorphisms on insulin resistance (IR) and beta cell function in Southern Mediterranean women with polycystic ovary syndrome (PCOS)

Russo Giuseppina T , Pappalardo Maria Angela , Giandalia Annalisa , Romeo Elisabetta L , Alibrandi Angela , Bari Flavia Di , Vita Roberto , Cucinotta Domenico , Benvenga Salvatore

The Pro12Ala and His447His polymorphisms of PPAR-γ, and Gly972Arg polymorphism of IRS-1 have been implicated in insulin resistance (IR) and adiposity. In this study, we investigated the possible influence of these polymorphisms on metabolic features of 53 PCOS women compared with 26 healthy women (controls). All women underwent a clinical, anthropometric and biochemical evaluation, including a 75-g oral glucose tolerance test; insulin secretion and sensitivity indices wer...