Endocrine Abstracts

Estradiol (E2), produced by granulosa cells (GCs) of ovarian follicles, plays an essential role in folliculogenesis by controlling follicular development and selection. E2 actions are principally mediated by the two nuclear receptors, ERα and ERβ. These two receptors are differently expressed in GCs, with ERβ being predominant. After ligand binding and receptor dimerization, ERα and ERβ mainly regulate gene transcription through direct interaction with...

Estradiol (E2) plays an essential role in woman fertility. E2, locally produced by granulosa cells (GCs) of ovarian antral follicles, controls follicular development and selection, and triggers the gonadotropin surge that leads to ovulation. Dysovulation arising from the arrest of antral follicle growth and maturation occurs in up to 10 % of reproductive-aged women suffering polycystic ovary syndrome (PCOS). Although the diagnostic criteria for PCOS are clearly established, th...