ea0092op-08-04 | Oral Session 8: Hypothyrodism / Nodules | ETA2023
Alwan Heba
, Luan Jian'an
, Williamson Alice
, Steward Isobel
, Wareham Nick
, Langenberg Claudia
, Pietzner Maik
Background: Numerous observational studies suggested that variation in thyroid function parameters even within the normal range associates with adverse, in particular non-thyroidal, health outcomes, but causality for most remains to be established.Methods: We combined individual level and summary level genetic prediction methods, i.e., polygenic scores and Mendelian randomization (MR), to systematically test for an association between liability to variat...