Searchable abstracts of presentations at key conferences in endocrinology

ea0029oc13.1 | Adrenal Basic | ICEECE2012

Targeting multiple signalling pathways showed high anti-tumour potential in two mouse phaeochromocytoma cell lines

Nolting S. , Garcia E. , Alusi G. , Korbonits M. , Grossman A.

Introduction: Since there is no completely effective therapy available for malignant phaeochromocytomas (PCCs) and paragangliomas, we have been investigating novel targeted therapies utilising one more benign (MPC) and one more malignant (MTT) PCC cell line. We have previously shown that the IGF1-receptor-inhibitor NVP-AEW541 led to compensatory ERK and mTORC1 up-regulation at suboptimal doses and that the dual PI3K/mTORC1-inhibitor NVP-BEZ235 also resulted in compensatory ERK...

ea0011oc18 | Clinical endocrinology | ECE2006

Endoscope-assisted pituitary surgery for functioning and non-functioning pituitary adenomas. The experience of the first 80 patients in a single centre

Hanson PL , Joshi SM , Alusi G , Sabin HI , Drake WM , Monson JP

Introduction: We present the outcome for the first 80 patients undergoing neuronavigation–guided, endoscopic transphenoidal surgery in our centre since August 2001. All operations were undertaken by the same neurosurgeon and endoscopic nasal surgeon.Indications for treatment: Indications for treatment may be divided into: Functioning microadenomas, with the aim of surgical cure while protecting residual pituitary function. Functioning macroadenomas,...