Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep106 | Adrenal medulla | ECE2017

Loss diagnosis of pheochromocytoma in the initial evaluation

Azevedo Teresa , Alves Marcia , Guimaraes Joana , Dantas Rosa , Balsa Ana Margarida , Inacio Isabel

Introduction: In most cases, adrenal masses are non-functioning adrenocortical adenomas. On ‘Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline’ published in 2016, the experts ‘suggest against repeated hormonal work-up in patients with a normal hormonal work-up at initial evaluation unless new clinical signs of endocrine activity appear or there is worsening of comorbidities’.C...

ea0032p40 | Adrenal cortex | ECE2013

Autoimmune polyglandular syndrome on a cohort of patients with primary adrenocortical insufficiency

Gouveia Sofia , Ribeiro Cristina , Alves Marcia , Saraiva Joana , Moreno Carolina , Guelho Daniela , Carrilho Francisco

Introduction: On average, 40 to 50% of the patients with autoimmune adrenocortical insufficiency will eventually develop an autoimmune polyglandular syndrome (APS). Our aim was to characterize a population with primary adrenocortical insufficiency (AI) and determine the prevalence of other autoimmune disorders that might establish the diagnosis of APS.Materials and methods: We included patients with primary AI under surveillance at our Department. Those ...

ea0026p302 | Obesity | ECE2011

Obesity in GDM

Ruas Luisa , Alves Marcia , Paiva Sandra , Marta Elvira , Lobo Antonio , Moura Paulo , Carvalheiro Manuela

Introduction: Retrospective study, 2003–07, of 619 GDM women.Patients and methods: Two groups according to pre-pregnancy BMI: Go ≥30, Gno <30 kg/m2. Influence of BMI in: family history of DM, previous GDM or macrossomia, gestational age at time of GDM diagnosis, weight gain, blood pressure, A1c, need and doses of Insulin, time and type of delivery, new- born weight, complications and re-evaluation post partum.<p class="abste...

ea0022p90 | Bone/Calcium | ECE2010

Primary hyperparathyroidism: retrospective evaluation

Santos Jacinta , Paiva Isabel , Barros Luisa , Vieira Alexandra , Alves Marcia , Gouveia Sofia , Carvalheiro Manuela

Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroid hormone (PTH), typically leading to hypercalcaemia. This disorder is more common than previously expected, since it is frequently diagnosed in asymptomatic patients.Objectives: To characterize a group of patients with PHP, in what concerns to: age, clinical presentation, biochemical and imaging evaluation, treatment and evolution.Pati...

ea0035p1009 | Thyroid (non-cancer) | ECE2014

Severe side effects of methimazole in the treatment of hyperthyroidism

Moreno Carolina , Alves Marcia , Paiva Isabel , Rodrigues Dircea , Ruas Luisa , Saraiva Joana , Guelho Daniela , Vicente Nuno , Cardoso Luis , Carrilho Francisco

Introduction: Methimazole is the thionamide compound most used in the treatment of hyperthyroidism due to its efficacy, commodity and security. Severe side effects are rare, although potentially fatal: agranulocytosis in 0.1–0.5% and toxic hepatitis in 0.1%Aims: To characterize the patients admitted in the endocrinology ward for the last 10 years for severe complications of methimazole therapy.Material and Methods: Retrospecti...

ea0032p267 | Clinical case reports – Pituitary/Adrenal | ECE2013

Treatment dilemmas of Cushing disease: case report

Saraiva Joana , Paiva Isabel , Alves Marcia , Gouveia Sofia , Moreno Carolina , Guelho Daniela , Gomes Leonor , Carvalheiro Manuela , Carrilho Francisco

Introduction: Cushing’s disease (CD) is a Grave disease that requires a multidisciplinary and individualized treatment approach.Case report: We describe the case of a 31-years old female patient with Cushing disease diagnosed in 2007. She initially complained of weight fluctuations, amenorrheia, rounded face with plethora and acne, for 1 year duration. Analytically: 0800 h plasma cortisol of 14 μg/dl (5–25) and 2300 h 15 μg/dl, ACTH 1...

ea0032p1101 | Thyroid cancer | ECE2013

Thyroglobulin levels in the washout of lymph node fine-needle aspirate on patients with previous history of differentiated thyroid cancer

Gouveia Sofia , Ribeiro Cristina , Paiva Sandra , Alves Marcia , Saraiva Joana , Moreno Carolina , Guelho Daniela , Leitao Fatima , Carrilho Francisco

Introduction: Our aim was to determine the comparable value of thyroglobulin in the washout of lymph node fine-needle aspirate (FNATg) and fine-needle aspiration biopsy (FNAB).Materials and methods: We included 29 patients (37 FNAB) with history of differentiated thyroid cancer who underwent total thyroidectomy and were found to have suspicious cervical lymph nodes during follow-up. The referred population was evaluated on what concerns to gender, age, s...

ea0026p229 | Pituitary | ECE2011

Clinical and subclinical apoplexy in nonfunctioning pituitary tumors: clinical features, management and outcome

Gomes Leonor , Paiva Isabel , Ribeiro Cristina , Santos Jacinta , Vieira Alexandra , Alves Marcia , Gouveia Sofia , Saraiva Joana , Rebelo Olinda , Carvalheiro Manuela

Background: Pituitary apoplexy occurs when a tumor undergoes acute hemorrhage, infarct, or both. This often leads to acute severe symptoms (clinical) but can also occur without them and diagnosed on CT/MRI, surgery, pathology (subclinical). To investigate clinical and subclinical apoplexy in nonfunctioning tumors (n=221) from our database.Design: Retrospective review of clinical presentation, tumor characteristics and outcome of 24 patients, 11 fe...

ea0022p185 | Clinical case reports and clinical practice | ECE2010

Primary biliary cirrhosis and Graves’ disease – combination rarely found

Vieira Alexandra , Paiva Sandra , Ribeiro Cristina , Santos Jacinta , Martinho Mariana , Alves Marcia , Gouveia Sofia , Carrilho Francisco , Carvalheiro Manuela

Introduction: The association of autoimmune diseases in the same individual is common. It is well documented that Graves’ disease (GD) is associated to various autoimmune diseases, including: pernicious anemia, vitiligo, type 1 diabetes, Addison’s disease, systemic sclerosis, myasthenia gravis, Sjogren’s syndrome, rheumatoid arthritis and systemic lupus erythematosus. In addition, primary biliary cirrhosis (PBC) may be associated with rheumatoid arthritis, Sjogr...

ea0022p217 | Clinical case reports and clinical practice | ECE2010

Malignant corticotrophinoma – a clinical report

Alves Marcia , Paiva Isabel , Santos Jacinta , Martinho Mariana , Vieira Alexandra , Gouveia Sofia , Belo Francisco , Bastos Margarida , Carvalheiro Manuela

Pituitary carcinoma is rare (0.1–0.2% of pituitary tumors), with a poor prognosis. It usually presents as invasive and secretory (ACTH or prolactin) macroadenoma. The diagnosis is confirmed by the presence of metastases. The latency period between the diagnosis of adenoma and carcinoma is variable (9.5 years for corticotrophinoma). The treatment includes surgery, radiotherapy and chemotherapy.We report a 58-year-old male, complaining of visual distu...