Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1107 | Female Reproduction | ECE2017

Efficacy of FSH alone, FSH + LH, hMG or FSH + hCG on ART outcomes in the ‘personalized’ medicine era: a meta-analysis

Santi Daniele , Casarini Livio , Alviggi Carlo , Simoni Manuela

Background: Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) act on the same receptor, activating different signal transduction pathways. The role of LH or hCG addition to follicle stimulating hormone (FSH) as well as menopausal gonadotropins (hMG) in controlled ovarian stimulation (COS) is debated.Aim: To compare FSH+LH, or FSH+hCG or hMG vs FSH alone on COS outcomes.Design: A meta-analysis according to PRISMA state...

ea0041ep599 | Endocrine tumours and neoplasia | ECE2016

Dual targeting of PIK3/AKT/mTOR and IGF1/KRAS/BRAF pathways in an in vitro model of ovarian cancer: strategies for cell proliferation control

de Angelis Cristina , Galdiero Giacomo , Pivonello Claudia , Patalano Roberta , Bifulco Giuseppe , Di Spiezio Sardo Attilio , Alviggi Carlo , De Placido Giuseppe , Colao Annamaria , Pivonello Rosario

Ovarian cancer (OC) is the most lethal gynecological cancer. Debulking surgery and platinum-based chemotherapy are the cornerstone of OC management; however, after a partial initial response, tumors invariably relapse. Therapeutic approaches should account for interindividual heterogeneity since OC histiotypes show distinct genetic profile. A2780 cell line has been annotated as high grade serous ovarian cancer (HGSOC); nevertheless, recent research underlined that the genetic ...

ea0041ep712 | Male Reproduction | ECE2016

The role of dopamine pathway on human sperm: in vitro effect of dopamine receptor agonists and antagonists on sperm motility, kinetics and viability

de Angelis Cristina , Cariati Federica , Galdiero Giacomo , Coppola Giorgio , Galdiero Mariano , Salzano Ciro , Pivonello Claudia , Patalano Roberta , Alviggi Carlo , De Placido Giuseppe , Colao Annamaria , Pivonello Rosario

Dopamine has been found in both semen and oviductal fluid and dopamine receptors (DRs) have been detected in male genital tract and spermatozoa, suggesting that dopamine system may control important reproductive functions in humans. Dopamine improves sperm motility and viability in animal models, although the underlying molecular mechanisms have not been fully elucidated. The aims of this study were to investigate DRs expression in human spermatozoa and to evaluate the in ...

ea0032p586 | Female reproduction | ECE2013

The combination of genetic variants in the FSHR and FSHB genes affect serum FSH in women of reproductive age

Moriondo Valeria , La Marca Antonio , Papaleo Enrico , Alviggi Carlo , Ruvolo Gianni , Giuseppe De Placido , Candiani Massimo , Cittadini Ettore , De Michele Francesca , Catellani Valeria , Volpe Annibale , Simoni Manuela

Introduction: The relationship between SNPs of the FSHR gene and serum FSH has not been completely clarified. Genetic variants of the FSHB gene have been associated to variation in gene transcription and to serum FSH levels in men. An interesting joint effect of both FSHB −211G>T and FSHR 2039 A>G on male reproductive parameters has been recently observed. No data have been published on the effect of the FSHB −211G>T in combination with the FSHR 2039 A&...