Searchable abstracts of presentations at key conferences in endocrinology

ea0099p447 | Calcium and Bone | ECE2024

Optimal strategies for vitamin D supplementation in the management of severe vitamin D deficiency

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Mohamed Shayma

Introduction: The uncertainty surrounding the optimal dose to rectify severe vitamin D deficiency (VDD) necessitates further investigation.Aim: To review and analyze various vitamin D (VD) supplementation doses, durations, and their effects on 25-hydroxyvitamin D (25OHD) levels, along with their biochemical and clinical outcomes, in the management of VDD.Methods: We reviewed intervention studies targeting VDD from databases (PubMed...

ea0099ep330 | Calcium and Bone | ECE2024

Early puberty and abnormal bone health: a comprehensive review

Soliman Ashraf , Alaaraj Nada , Alyafei Fawzia , Hamed Noor , Mohamed Shayma

Introduction: The relationship between early puberty and abnormal bone health has garnered significant research attention, with varying outcomes. Objectives: This review systematically examines studies up to March 2023 to determine whether early puberty is associated with abnormal bone health, specifically low bone mineral density (BMD), osteopenia, and osteoporosis. We analyze and summarize research articles (n=25) to elucidate the potential li...

ea0099ep395 | Calcium and Bone | ECE2024

Linear growth and response to GH therapy in short children with normal vs low IGF1 level and normal BMI at presentation

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Mohamed Shayma

We conducted a longitudinal study on 95 children presented to pediatric clinic with short stature. Children were classified to low IGF1 (IGF1SDS <-1) (n=25) and normal IGF1 (IGF1SDS >-1) (n=70) and treated with human GH (0.03: 0.05 mg/kg/day) for 2 years. Anthropometrics data (HtSDS, difference from mid-parental height SDS (MPHSD), BMISDS, bone age and IGF1 level were studied for 2 years.Results: At presentation, the age, bone a...

ea0099ep648 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

The Relationship between Precocious/Early Puberty and Obesity with Metabolic Abnormalities: A Comprehensive Review

Soliman Ashraf , Alaaraj Nada , Alyafei Fawzia , Hamed Noor , Mohamed Shayma

The Relationship between Precocious/Early Puberty and Obesity with Metabolic Abnormalities: A Comprehensive ReviewIntroduction: The impact of pubertal timing on the development of obesity and metabolic abnormalities has been the subject of extensive research with variable outcomes. Objective: We systematically reviewed studies (Medline, Pubmed, Google scholar, and Web of Science) 2000 until March 2023 evaluating the relation betwee...

ea0099ep649 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Prevalence of Metabolic Syndrome Components and High Atherogenic Index in Obese Nondiabetic Children

Soliman Ashraf , Hamed Noor , Alyafei Fawzia , Alaaraj Nada , Mohamed Shayma

This study aimed to explore the prevalence of distinct Metabolic Syndrome (MetS) components and plasma AIP among obese children and adolescents, and to evaluate their anthropometric measures in comparison to their parents, thereby considering genetic and environmental influences.Methodology: Anthropometric and biochemical profiles of 91 randomly selected obese children and young adolescents (mean age: 10.5&pm;2.7 years) were meticulously analyzed. This c...

ea0099ep339 | Endocrine-Related Cancer | ECE2024

The association between early/precocious puberty and the risk of breast cancer

Soliman Ashraf , Alaaraj Nada , Alyafei Fawzia , Hamed Noor , Mohamed Shayma

Introduction: The contribution of reproductive factors to breast cancer (BC) susceptibility requires further investigation. This study aims to explore the potential link between early puberty (menarche) and the risk of breast cancer in women.Aim: This study systematically reviews research conducted between 2000 and March 2023, aiming to evaluate the association between early/precocious puberty and the incidence of BC.Methods: A com...

ea0099ep1193 | Pituitary and Neuroendocrinology | ECE2024

Pediatric pituitary microadenomas: a case series and review of diagnostic challenges and treatment outcomes

Soliman Ashraf , Hamed Noor , Alaaraj Nada , Alyafei Fawzia , Ahmed Shayma

Background: Pituitary microadenomas in pediatric populations, though infrequent, present diagnostic and therapeutic challenges.Methods: We retrospectively reviewed six pediatric cases of pituitary microadenomas diagnosed and treated at our institution. The cases were analyzed for presenting symptoms, hormonal profiles, and treatment responses.Results: Case 1: A 12-year-old with growth hormone deficiency showed significant height im...

ea0099ep1271 | Late Breaking | ECE2024

The short and long-term potential negative effects of thyroxine therapy in children and adolescents

Soliman Ashraf , Alaaraj Nada , Hamed Noor , Mohamed Shayma , Alyafei Fawzia

Introduction: This review aims to systematically analyze and summarize the findings from research articles regarding the potential short-term and long-term side effects of L-thyroxine therapy in children and adolescents. The selection criteria for the studies included their focus on the negative effects of thyroxine therapy related to thyroid health, cognitive function, cardiovascular health, bone health, and cancer risk in pediatric populations. Results...

ea0099ep1339 | Late Breaking | ECE2024

Pediatric pituitary microadenomas: a spectrum of clinical presentations and therapeutic responses"

Hamed Noor , Alaaraj Nada , Mohamed Shayma , Alyafei Fawzia , Soliman Ashraf

Pituitary microadenomas in children and adolescents are relatively rare, accounting for a small percentage of pediatric endocrine disorders. These benign tumors often present a diagnostic challenge due to their subtle and variable clinical manifestations at this young age. We present clinical and lab data of 5 children with pituitary microadenoma. Case 1: A 12-year-old female with a history of short stature and slow growth velocity was diagnosed with a small pituitary microade...

ea0099ep480 | Calcium and Bone | ECE2024

Maternal vitamin d supplementation during pregnancy and lactation: effects on maternal and infantile vitamin d status

Soliman Ashraf , Alyafei Fawzia , Alaaraj Nada , Hamed Noor , Mohamed Shayma , Itani Maya

This review assessed recent literature (RCTs, longitudinal studies, meta-analyses) from the past decade via PubMed, Google Scholar, and Scopus to gauge the impact of prenatal and postnatal vitamin D (VD) supplementation on maternal and infantile vitamin D status.Results: We analyzed 12 studies (n=6253 mothers). In a prospective interventional study involving 80 women who received two doses of VD injections (600,000 IU/ml each), 60% of women disp...