Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep350 | Endocrine tumours and neoplasia | ECE2017

A suspicious case of multiple endocrine neoplasia

Pereira Teresa Alves , Furtado Ines , Amado Ana , Ferreira Lia , Almeida Raquel , Palma Isabel

Introduction: Multiple endocrine neoplasia (MEN) syndromes are rare entities characterized by the occurrence of tumors involving two or more endocrine glands in a single patient. These syndromes are classified as type 1 or 2 according to specific phenotypic characteristics. MEN2 encompasses three different subtypes: MEN2A, MEN2B and familial medullary thyroid carcinoma. More recently a syndrome related to mutations in the CDKN1B gene has been described – the syndrome of m...

ea0049ep1279 | Thyroid (non-cancer) | ECE2017

Metastatic differentiated thyroid carcinoma: cumulative doses of adjunct 131i-iodide therapy

Gouveia Patricia , Pereira Teresa , Amado Ana , Teixeira Ricardo , Costa Antonio , Carvalho Andre , Freitas Claudia , Borges Fatima

Introduction: 131I-iodide therapy (RIT) is an important treatment modality for patients with differentiated thyroid carcinoma (DTC). However, despite the overall excellent outcome, some DTC patients with poor prognosis may require multiple doses of radioactive iodine.Aim: The purpose of our study was to evaluate the efficacy of cumulative doses (CDs) of RIT in metastatic DTC patients.Material and methods: A retrospective study was ...

ea0056p886 | Pituitary - Clinical | ECE2018

Acromegaly: surgical results and predictors for remission

Amado Ana , Figueiredo Goncalo , Ribeiro Isabel , Amaral Claudia , Borges Fatima , Cardoso Helena

Introduction: Acromegaly is a rare disease with significant morbidity and mortality. Surgical treatment is the first line treatment for these patients, with remission rates of >85% for microadenomas and 40–50% for macroadenomas.Objectives: Our objective was to characterize patients with acromegaly followed in our department and evaluate remission status after surgery. We also aimed to determine remission related factors.Me...

ea0049gp228 | Thyroid Cancer | ECE2017

Differentiated thyroid cancer – comparison between patients with and without remission

Amado Ana , Gouveia Patricia , Pereira Teresa Alves , Castro Rosa , da Costa Antonio Moreira , Carvalho Andre , Freitas Claudia , Borges Fatima

Introduction: Differentiated thyroid cancer (DTC) is one of the most frequent forms of malignancy. Because of its favourable outcome and low mortality rates, identifying prognostic factors has been a challenge. Several risk stratification systems have been developed. Most of them include demographic and tumour specific features, as well as extrathyroidal extension. Our objective was to compare clinical characteristics between DTC patients with and without remission.<p clas...

ea0063gp220 | Gestational and Type 1 Diabetes | ECE2019

Definition of a third-trimester HbA1c cut-off point for an increased risk of Large-for-Gestational-Age in mothers with Gestational Diabetes

Fonseca Liliana , Duarte Diana Borges , Amado Ana , Lau Eva , Pichel Fernado , Goncalves Joaquim , Pinto Clara , Vilaverde Joana , Dores Jorge , Cardoso Helena

Introduction: Gestational diabetes mellitus (GDM) is associated with important neonatal risks and a higher incidence of large-for-gestational-age (LGA) newborns and fetal macrosomia. The aim of our work was to define a third-trimester HbA1c cut-off point for increased risk of fetal morbidity, macrosomia and LGA newborns.Methodology: Observational retrospective study of all singleton pregnant women with GDM, followed at our Diabetes and Pregnancy Clinic b...

ea0063p919 | Diabetes, Obesity and Metabolism 3 | ECE2019

Diabetes Eruditus: Characteristics of type 1 diabetes of long duration

Duarte Diana Borges , Amaral Claudia , Amado Ana , Teixeira Sofia , Carvalho Andre , Vilaverde Joana , Freitas Claudia , Palma Isabel , Dores Jorge , Carvalho Rui , Bacelar Conceicao , Ramos Helena , Cardoso Helena

Introduction and aim: Type 1 diabetes mellitus (T1DM) presents as a challenge for both health care providers and patients looking to avoid chronic complications and early mortality. Clinical features of patients with long duration T1DM are still poorly studied and debated. The aim of our work was to describe the clinical features of subjects with long duration T1DM.Methods: Cross-sectional study of patients with T1DM with more than 40 years of evolution ...

ea0049gp229 | Thyroid Cancer | ECE2017

Trends in papillary microcarcinoma prevalence in North of Portugal

Pereira Teresa Alves , Amado Ana , Gouveia Patricia , Castro Rosa , da Costa Antonio Moreira , de Carvalho Andre Couto , Freitas Claudia , Borges Fatima

Introduction and Objectives: The incidence of thyroid cancer has increased worldwide. This increase has been attributed to more diagnosed papillary thyroid microcarcinomas. The purpose of this study was to analyse the growing trend of first appointments in our Thyroid Cancer Unit, namely patients with papillary microcarcinomas.Methods: We performed a retrospective study based on the patients diagnosed with thyroid cancer between 1960 and 2016. We divided...

ea0049ep496 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Maturity onset diabetes of the young - clinical characteristics of a portuguese cohort

Amado Ana , Almeida Raquel , Carvalho Andre , Amaral Claudia , Freitas Claudia , Bacelar Conceicao , Vilaverde Joana , Cardoso Maria Helena , Teixeira Sofia , Borges Fatima

Introduction: Maturity onset diabetes of the young (MODY) accounts for 1-2% of all forms of diabetes mellitus (DM). As classic criteria that lead to its suspicion have low sensitivity, patients are often misdiagnosed with type 1 or type 2 DM. Correct classification of this type of diabetes becomes essential for proper management of the disease. Our objective was to describe clinical features of patients with MODY diagnosed at our institution.Methods: We ...

ea0037ep311 | Calcium and Vitamin D metabolism | ECE2015

Primary hyperparathyroidism presented as humeral brown tumor and multiple bone fractures

Ferreira Lia , Gomes Pedro , Cardoso Pedro , Valente Vitor , Amado Ana , Pereira Maria Teresa , Garrido Susana , Almeida Raquel , Freitas Claudia , Amaral Claudia , Palma Isabel , Borges Fatima

Primary hyperparathyroidism (PHPT) is frequently diagnosed as an incidental finding of hypercalcemia. Overt bone disease (osteitis fibrosa cystica or brown tumor), with history of pathologic fractures is a rare presentation.A 48-year-old woman was admitted in with pain in the right thigh after a trivial fall. She also complained of generalized weakness and lethargy over the last 2 years. Her medical history mention multiple bone fractures in the last 6 y...

ea0049ep1049 | Pituitary - Clinical | ECE2017

Aggressive pituitary tumours: a multicenter study

Palha Ana , Gomes Leonor , Sequeira Duarte Joao , Marques Conceicao , Amaral Claudia , Amado Ana , Borges Fatima , Ribeiro Isabel , Barreiros Eduardo , Barreiros Luis , Miguens Jose , Joao Bugalho Maria , Lages Adriana , Paiva Isabel , Marques Olinda , Almeida Rui , Martins Teresa , Cortez Luisa , Agapito Ana , Fonseca Fernando

Introduction: Pituitary tumours are considered benign, however some exhibit an aggressive behavior. Defining a timely treatment is challenging due to absence of accurate prognostic predictors.Objective: To evaluate radiological and histopathological features of aggressive pituitary tumours.Methods: Multicenter and retrospective study. Criteria for aggressiveness were: invasion to sphenoid and/or cavernous sinus; growth progression ...