Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep311 | Calcium and Vitamin D metabolism | ECE2015

Primary hyperparathyroidism presented as humeral brown tumor and multiple bone fractures

Ferreira Lia , Gomes Pedro , Cardoso Pedro , Valente Vitor , Amado Ana , Pereira Maria Teresa , Garrido Susana , Almeida Raquel , Freitas Claudia , Amaral Claudia , Palma Isabel , Borges Fatima

Primary hyperparathyroidism (PHPT) is frequently diagnosed as an incidental finding of hypercalcemia. Overt bone disease (osteitis fibrosa cystica or brown tumor), with history of pathologic fractures is a rare presentation.A 48-year-old woman was admitted in with pain in the right thigh after a trivial fall. She also complained of generalized weakness and lethargy over the last 2 years. Her medical history mention multiple bone fractures in the last 6 y...

ea0035p764 | Obesity | ECE2014

Improvement of type 2 diabetes after gastric banding and gastric bypass: medium-term outcomes

Caldas Ana Rita , Pereira Teresa , Garrido Susana , Freitas Claudia , Amaral Claudia , Carvalho Andre , Silva Isabel , Pichel Fernando , Silva Carla , Silva Antonio Sergio , Nogueira Carlos , Santos Jorge , Marcos Mario , Cardoso Maria Helena

Introduction: Bariatric surgery is associated with improvement and often resolution of type 2 diabetes mellitus (T2DM). Our aim was to compare the effects of gastric banding (GB) and gastric bypass (GBP) in glucose homeostasis in obese patients with T2DM.Methods: From 1995 to 2011, 83 diabetic patients underwent bariatric surgery at our hospital: 37 underwent GB (73% females, mean age 48.3±9.2) and 46 underwent GBP (82.6% females, mean age ...

ea0081ep674 | Pituitary and Neuroendocrinology | ECE2022

Cushing’s disease and health-related quality of life: a cure for all dimensions?

Duarte Diana Borges , Puga Francisca , Ribeiro Isabel , Amaral Claudia

-Diana Borges Duarte and Francisca Puga are joint first authors and contributed equallyBackground: As therapeutic options improve for Cushing’s disease (CD), most patients can now achieve control or cure of hypercortisolism. However, persistent complaints are often reported. Evaluation of health-related quality of life (HR-QoL) can highlight impairments beyond the stricter clinical aspects. Our aim was to evaluate HR-QoL with a specific focus on men...

ea0049ep30 | Adrenal cortex (to include Cushing's) | ECE2017

Severe hypoaldosteronism after unilateral adrenalectomy for primary hyperaldosteronism

Goncalves Joao Ananias , Barrros Rui , Ferreira Betania , Amaral Claudia

Introduction: Primary hyperaldosteronism is a known cause of arterial hypertension, classically with hypokalaemia. About 30–40% of the cases are caused by unilateral aldosterone-producing adenoma, and the recommended treatment is adrenalectomy. Hypoaldestoronism is an uncommon complication of unilateral adrenalectomy, but it can be life-threatening. We present a case of severe hypoaldosteronism after unilateral adrenalectomy for the treatment of primary aldosteronism....

ea0056p63 | Adrenal cortex (to include Cushing's) | ECE2018

Salivary cortisol as a diagnostic tool for hypercortisolism in Cushing’s syndrome and adrenal incidentaloma

Ferreira Lia , Amaral Claudia , Palma Isabel , Cardoso Helena

Background: The lack of circadian rhythm is a marker of Cushing’s syndrome (CS). Therefore, salivary cortisol rhythm has been suggested for studies on the hypothalamic–pituitary–adrenal (HPA) axis. Late-night salivary cortisol has been used recently by many centers as a first line diagnostic test for CS, yet its accuracy is still on debate.Aim: To evaluated the performance of morning and late night salivary cortisol in patients with CS and...

ea0081p213 | Thyroid | ECE2022

Tuberculosis and myxedema coma − clinical case

Saraiva Miguel , Maia Ariana , Assuncao Guilherme , Amaral Claudia , Freitas Claudia , Couto de Carvalho Andre

Introduction: Myxedema coma is the ultimate stage of severe long-standing hypothyroidism, representing a true endocrinological emergency. Many precipitating factors have been identified, including the initiation of certain drugs.Case report: An 89-year-old woman was admitted to our emergency department due to an inaugural seizure. There was a history of progressive functional deterioration in the last 7 weeks, short after being diagnosed with lymph node ...

ea0049ep921 | Neuroendocrinology | ECE2017

Kallmann syndrome: about eleven clinical cases

Fonseca Liliana , Amaral Claudia , Dores Jorge , Palma Isabel , Carvalho Rui , Cardoso Helena , Vilaverde Joana , Borges Fatima

Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder that is primarily caused by a gonadotrophin-realising hormone (GnRH) deficiency. When CHH is associated with hyposmia or anosmia is designated by Kallmann Syndrome (KS). This syndrome is a genetic disorder with significant genetic heterogeneity that may present as a sporadic or familial case, following autosomal dominant, autosomal recessive, or X – linked recessive modes of inherita...

ea0035p329 | Clinical case reports Thyroid/Others | ECE2014

Two serious complications of propylthiouracil treatment in the same patient: case report

Garrido Susana , Pereira Teresa , Marinho Antonio , Freitas Claudia , Vilaverde Joana , Amaral Claudia , Carvalho Andre , Borges Fatima

Introduction: Thionamides are important drugs in the treatment of hyperthyroidism. Despite that, they can be associated with rare but serious complications, which require drug discontinuation.Case report: Sixty-five-year-old woman with Graves’ disease, treated in 2002 with methimazole and in remission until 2012. Recurrence of Graves’ disease was diagnosed in March 2012 and she was started on propylthiouracil (PTU) 150 mg per day. She presented...

ea0035p457 | Diabetes complications | ECE2014

Diabetic ketoacidosis and olanzapine: case report

Garrido Susana , Pereira Teresa , Freitas Claudia , Vilaverde Joana , Amaral Claudia , Carvalho Andre , Borges Fatima

Introduction: Patients with psychotic or depressive disorders have an increased risk of developing metabolic syndrome, not only because of their unhealthy lifestyle (sedentary habits, inadequate diet and smoking) but also because of the negative impact of antipsychotic agents (specially clozapine and olanzapine) on several metabolic features. These include overweight/obesity, dyslipidemia, development of new-onset type 2 diabetes, worsening of pre-existing diabetes and diabeti...

ea0022p225 | Clinical case reports and clinical practice | ECE2010

Necrotizing fasciitis as a complication of subcutaneous injection of insulin in a diabetic patient: a case report

Teixeira Sofia , Silva Ana Maia , Giestas Anabela , Vaz Daniel , Amaral Claudia

Necrotizing fasciitis is a rare infection of the soft tissues with consequent necrosis of fascial planes and surrounding tissues. If misdiagnosed or not properly treated it can be fatal. It typically follows trauma and it have already been described after intramuscular or intravenous injection of insulin.The authors present a case of a 24-year-old man, with type 1 diabetes mellitus for more than ten years, admitted to the emergency room for diabetic keto...