Endocrine Abstracts

Background and aims: The contribution of myokines to improved glucose homeostasis induced by bariatric surgery is unknown. Our study aims to identify myokines potentially improving glucose homeostasis following bariatric surgery.Patients and methods: Obese insulin-resistant patients were evaluated before and 3 months after bariatric surgery, i.e. a sleeve gastrectomy or a Roux-en-Y gastric bypass (n62). Muscle biopsies were taken from vastus lat...

Objective: We describe two first cousins presenting with neonatal corticotropic deficiency and severe, early-onset obesity. This study aims to identify the molecular etiology of these disorders in both cases and highlights the limits of genetic investigations.Methods: We collected the clinical-biological data of the family and, more particularly, of the two first cousins (A and B). We performed several constitutive Next-generation Sequencing (NGS) protoc...

Purpose: Our study aims to identify myokines potentially involved in improved glucose homeostasis after bariatric surgery.Methods: Obese patients were evaluated before and 3 months after bariatric surgery. Insulin resistance was assessed using the Homeostasis Model Assessment (HOMA) test. Muscle biopsies were taken from vastus lateralis. Genes encoding myokines involved in glucose homeostasis were identified using RNA-sequencing. Changes in myokines expr...