Searchable abstracts of presentations at key conferences in endocrinology

ea0090p546 | Late-Breaking | ECE2023

Polycythemia vera and feminizing hormone treatment in an individual Assigned Male at Birth (AMAB): a prickly situation

Parazzoli Chiara , Delle Donne Elisa , Federici Silvia , Amer Myriam , Persani Luca , Bonomi Marco , Bonadonna Stefania

Introduction: Feminizing hormone therapy (HT) for male-assigned at birth (AMAB) includes estrogens, often in combination with anti-androgens. Several studies have reported an increased incidence of cardiovascular diseases and venous thromboembolism in AMAB receiving estrogens. Indeed, procoagulant changes induced by estrogen-based HT occur in transwomen as well as in cisgender individuals. Therefore, using estrogen in gender-affirming HT is relatively contraindicated in those ...

ea0090p270 | Late-Breaking | ECE2023

Monitoring serum estradiol levels in clinical practice: a retrospective study in transgender AMAB subjects

Federici Silvia , Garofalo Chiara , Parazzoli Chiara , Amer Myriam , Delle Donne Elisa , Persani Luca , Bonadonna Stefania , Bonomi Marco

The Standards of Care version 8 (SOC 8) for transgender and gender diverse people suggest maintaining estradiol (E2) levels between 100-200 pg/ml in Assigned Male at Birth (AMAB) subjects who desire a complete feminization during gender affirmation hormone therapy (GAHT). However, data about estrogen dose therapy and corresponding serum concentrations are scarce, especially regarding gel formulations. Our aim was to retrospectively compare E2 serum levels in AMAB patients unde...

ea0070aep133 | Bone and Calcium | ECE2020

Prevalence and determinants of radiological vertebral fractures in a cohort of patients with Klinefelter syndrome

Vena Walter , Pizzocaro Alessandro , Amer Myriam , Indirli Rita , Maffezzoni Filippo , Ferrante Emanuele , Delbarba Andrea , Balzarini Luca , Ferlin Alberto , Mantovani Giovanna , Lania Andrea , Mazziotti Gherardo

Klinefelter syndrome (KS) is a frequent form of male hypogonadism that may be associated with a series of comorbidities potentially affecting quality of life and survival. As a matter of fact, KS was shown to negatively impact skeletal health. However, the studies so far published on this topic were mainly focused on evaluation ofbone mineral density (BMD) and bone microstructure, whereas data on fracture risk are still lacking. In this cross-sectional study, we evaluated for ...

ea0075r06 | Reproductive Endocrinology | EYES2021

Low testosterone is a predictor of hypoxemic respiratory insufficiency and higher mortality rate in SARS-CoV-2 hospitalized patients: A cohort study

Vena Walter , Pizzocaro Alessandro , Maida Giulia , Amer Myriam , Voza Antonio , Di Pasquale Andrea , Reggiani Francesco , Ciccarelli Michele , Fedeli Carlo , Lavezzi Elisabetta , Mazziotti Gherardo , Lania Andrea

Objective: To evaluate the association between testosterone (T) values and clinical outcome of COVID-19.Methods: This is a retrospective single-center study performed on 221 male patients (median age 70.5 years, range 26-93) with COVID-19 and hospitalized in our Institution between November 1st 2020 and January 31st 2021. PatientsÂ’ height, weight, BMI, medical history and comorbidities were recorded; at admission, patients underwent sampling for com...