Searchable abstracts of presentations at key conferences in endocrinology

ea0028p312 | Steroids | SFEBES2012

Effects of In-Utero Exposure to Endocrine Disruptors on the Ovine Fetal Adrenal Gland

Buckley Charlotte , Danga Mercy , Hogg Kirsten , Amezaga Maria , Rhind Stewart , Fowler Paul , Rae Michael , Morley Steven

Introduction: The repercussions of long-term exposure to low level mixtures of endocrine disrupting compounds (EDCs) which are present, ubiquitously, in the environment are not well understood. Heat-treated sewage sludge, an EDC-rich product used as fertiliser, has been shown to compromise testicular and ovarian development. However, to date, there has been limited investigation in exposed animals of the adrenal glands, the steroid hormone products of which play key roles in f...

ea0038p250 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Lifelong exposure to sewage sludge chemicals causes proteome-wide and sex-specific disturbances in the liver

Filis Panagiotis , Eaton-Turner Emily , Bellingham Michelle , Amezaga Maria , Mandon-Pepin Beatrice , Evans Neil , Sharpe Richard , Cotinot Corinne , Rhind Stewart , O'Shaughnessy Peter , Fowler Paul

Introduction: A complex cocktail of endocrine-disrupting and other chemicals is ubiquitous in the modern environment. Exposure to such chemicals contributes to diseases including metabolic syndrome and infertility. The liver is the primary defence organ against xenotoxicants, but also the source of major of plasma proteins, and growth factors/hormones.Aim: To understand how chronic exposure to complex mixtures of chemicals at human and environmentally re...