Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp230 | Thyroid Cancer | ECE2017

Radioiodine (RAI) refractory differentiated thyroid cancer (DTC): outcome and prognostic factors for DISEASE progression

Saltiki Katerina , Simeakis George , Anagnostou Elli , Apostolakis Michalis , Zapanti Evangelia , Anastasiou Eleni , Alevizaki Maria

Introduction: Patients diagnosed with DTC have excellent prognosis. A small percentage of patients with disease persistence do not respond to treatment with RAI (RAI-refractory DTC) and have low median survival (3.5 years). We investigated the prognostic factors and the disease course in patients with RAI-refractory DTC.Methods: Of all DTC patients (n=1160) followed-up in our department in recent years, 800 received RAI treatment and were classified in 2...

ea0049ep1411 | Thyroid (non-cancer) | ECE2017

Clinical features of medullary thyroid carcinoma (MTC) in simultaneous occurrence with differentiated thyroid cancer (DTC)

Simeakis George , Saltiki Katerina , Anagnostou Elli , Apostolakis Michalis , Vasileiou Vasiliki , Alevizaki Maria

Objective: Simultaneous occurrence of MTC and DTC is frequently found. It is unclear whether there is a common pathogenic mechanism. Aim of our study was to characterize clinical features of MTC when coexisting with DTC.Methods: Of 273 MTC patients followed-up in our department 39 (14.3%) had MTC simultaneously with DTC. They were divided in 4 subgroups according to size. Clinical histopathological data were recorded.Results: The p...

ea0041gp237 | Thyroid Cancer (1) | ECE2016

The origin of patients with inherited medullary thyroid cancer, who are carriers of the rare exon 8 mutation (G533C) of the RET gene in Greece

Saltiki Katerina , Anagnostou Elli , Angelopoulou Anastasia , Kouki Sofia , Apostolakis Michail , Sarika Lida , Papathoma Alexandra , Alevizaki Maria

Introduction: Mutations in the ret gene are responsible for the transmission of inherited medullary thyroid cancer (MTC). In recent years a high prevalence of the ‘rare’ exon 8 mutation (G533C) has been found in patients with inherited MTC in Greece. The aim of this study was to record with more detail the place of origin of these families in the country.Design: We analysed the details of 44 patients belonging to 22 families who were c...

ea0041ep353 | Clinical case reports - Thyroid/Others | ECE2016

Malignant struma ovarii causing thyrotoxicosis

Anagnostou Elli , Polymeris Antonios , Morfopoulos Georgios , Travlos Alexios , Sarantopoulou Vassiliki , Papasryrou Eirini

Introduction: Struma ovarii (SO) is a specialized monodermal teratoma predominantly composed of mature thyroid tissue (>50%). It accounts for ~5% of all ovarian teratomas. Thyrotoxicosis is seen in about 8% of patients with SO. Most struma ovarii are benign with only 5–10% being malignant. Malignant SO causing thyrotoxicosis is very uncommon.Case presentation: A 64-year-old woman had been diagnosed with thyrotoxicosis 2 years ago. The thyroid gl...

ea0041ep837 | Obesity | ECE2016

Metabolic syndrome and insulin resistance: can they be predicted by clinical indicators in obese prepubertal children?

Vlachopapadopoulou Elpis , Dikaiakou Eirini , Petrou Vasilis , Anagnostou Elli , Karachaliou Feneli , Patinioti Ioanna , Fotinou Aspasia , Michalacos Stefanos

Aim: To evaluate whether anthropometric indices and acanthosis nigricans can be useful markers for early detection of Insulin Resistance and Metabolic Syndrome (MetS) in overweight and obese children.Methods: Data from 510 prepubertal children (40% boys), 12.9% overweight and 87.1% obese with mean age 9.7±2.5 years were analyzed. Logistic regression analysis was used to investigate which factors were associated with HOMA-IR >3 and metabolic synd...

ea0049gp45 | Bone & Calcium Homeostasis 2 | ECE2017

Methylation patterns at the novel DMR of GNAS (GNAS-AS2) in pseudohypoparathyroidism 1B (PHP1B or iPPSD3) subtypes

Hanna Patrick , Rochtus Anne , Jueppner Harald , Mackay Deborah , Francou Bruno , Bouligand Jerome , Mantel Anne , Anagnostou Elli , Gaillard Dominique , Linglart Agnes

PHP1B -iPPSD3 per the new proposed classification- is a rare disorder characterized in most patients by proximal tubular resistance to PTH resulting in hypocalcemia, hyperphosphatemia and elevated PTH. Loss-of-methylation (LOM) at the Differentially Methylated Region (DMR) at GNAS exon A/B occurs in all PHP1B patients, but methylation changes at other DMRs within GNAS occur in some familial and most sporadic PHP1B cases. All patients with autosomal dominant PHP1B (AD-...

ea0063p873 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Immunohistochemical expression of ephrines A2 and A4 receptors in neuroendocrine neoplasms: preliminary results

Alexandraki Krystallenia , Antonopoulou Ioanna , Karaflou Maria , Christakou Charikleia , Mavroeidi Vasiliki , Karapanagioti Aggeliki , Lekkakou Maria , Anagnostou Elli , Tsoli Marina , Angelousi Anna , Delladetsima Ioanna Kassiani , Felekouras Evangelos , Sotiropoulos Georgios , Kaltsas Gregory , Theocharis Stamatios

Introduction: Ephrin receptors (EPHs) have a role in tumor growth, invasion, angiogenesis and metastasis of several neoplasms. Aim of the study was to investigate the expression and possible clinical significance of EPH-A4 and EPH-A2 protein expression in the pathophysiology of neuroendocrine neoplasms (NENs).Methods: EPH-A4 and -A2 protein expression was assessed by immunohistochemical analysis along with Ki-67 proliferation index (%) on 28 paraffin emb...