Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep188 | Endocrine tumours and neoplasia | ECE2017

An elevated chromogranin A: is it always a tumor progression?-case report

Bursuc Anamaria , Daniela Belceanu Alina , Armasu Ioana , Tirnovan Mirela , Manolachie Adina , Crumpei Felicia , Ciobanu Delia , Leustean Letitia , Vulpoi Carmen

Introduction: Pancreatic neuroendocrine tumors (PNET) are rare, with an incidence of 1/100,000/year. Chromogranin A (CgA) is the most valuable marker in the diagnosis and monitoring of PNET. One of the disadvantages is its low specificity and the existence of a number of processes leading to an increase in its concentration, which often results in confusion and diagnostic difficulties.Case report: We present a 44-years-old female patient...

ea0049ep1073 | Pituitary - Clinical | ECE2017

Aggressive macroprolactinoma – exception to the rule

Belceanu Alina Daniela , Constantinescu Georgiana , Crumpei Iulia , Bursuc Anamaria , Rotariu Daniel , Constantinescu Aurora , Ciubotaru Vasile , Preda Cristina , Vulpoi Carmen

Background: Prolactinoma is the most frequent pituitary tumour. However, peculiar aspects may induce difficulties in their evolution and management. Malignant prolactinoma is exceptionally rare and it cannot be diagnosed on histological grounds alone. We report the case of a recurrent, possibly malignant macroprolactinoma.Case report: 46 years old female, addressed for bitemporal hemianopia, without other clinical signs. MRI confirmed a pituitary macroad...

ea0049ep1076 | Pituitary - Clinical | ECE2017

Pituitary adenoma and elevated ACTH: not always corticotrophinoma

Cabac Mariana , Belceanu Alina Daniela , Crumpei Iulia , Tirnovan Mirela , Constantinescu Georgiana , Bursuc Anamaria , Constantinescu Aurora , Mogos Voichita , Vulpoi Carmen

Introduction: Hypothalamic┬ľpituitary┬ľadrenal (HPA) axis activation is the main neuroendocrine response to an environmental challenge. Drug abuse may activate HPA axis by interaction with neuromodulation systems.Case report: 28 year old man, was admitted in the Neurology Department for persistent headache with spinal irradiation. With suspicion of multiple sclerosis, MRI revealed pituitary macroadenoma (14 mm diameter) and subcortical, paraventr...

ea0049ep1209 | Clinical case reports - Thyroid/Others | ECE2017

Autoimmune thyroid disease occurring as a possible late complication after a non-occupational HIV Postexposure Prophylaxis

Crumpei Iulia , Mogos Voichita , Ungureanu Maria-Christina , Bursuc Anamaria , Armasu Ioana , Tirnoveanu Mirela , Adomnicai Valentina , Constantinescu Georgiana , Vulpoi Carmen

Introduction: Nonoccupational postexposure prophylaxis (nPEP) is a three-drug antiretroviral regimen used to decrease the risk for HIV infection after less than 72 h from nonoccupational exposure to body fluids that might contain HIV. The most frequent side effects concern the gastro-intestinal intolerance, renal and hepatic toxicity, with no hormonal imbalance to have been yet reported.Case report: 24 years old male patient, consulted for palpitations, ...

ea0049ep1360 | Thyroid (non-cancer) | ECE2017

Mirela Tirnovan1, Anamaria Bursuc1, Alina Daniela Belceanu1, Adina Manolachie1, Ioana Armasu1, Iulia Crumpei1, Georgiana Constantinescu1, Luminita Apostu2, Carmen Vulpoi1

Tirnovan Mirela , Bursuc Anamaria , Belceanu Alina Daniela , Armasu Ioana , Crumpei Iulia , Manolachie Adina , Apostu Luminita , Vulpoi Carmen

Introduction: Many causes of malabsorbtion of levothyroxine (LT4) in patients with hypothyroidism have been thoroughly described in literature. Pseudomalabsorption, poor compliance of the patient is most common cause of failure of LT4 and/or liothyronine (LT3) treatment.Case report: 27 years old woman, normopondeal, presented from the age of 11 years for short stature. Further investigations found pluritrope pituitary insufficiency ...

ea0041ep304 | Clinical case reports - Pituitary/Adrenal | ECE2016

Association of two aggressive tumors (prolactinoma and multiple meningioma) – difficult issue, difficult management

Constantinescu Georgiana , Belceanu Alina , Haba Danisia , Constantinescu Aurora , Rotariu Daniel , Bursuc Anamaria , Armasu Ioana , Preda Cristina , Vulpoi Carmen

Introduction: The coexistence of pituitary adenoma and meningiomas is very rare. It is debatable if meningiomas result as a consequence of hormone dependent growth or secondary to radiation.We report a rare case of coexisting brain tumors: a prolactin secreting pituitary adenoma and two meningiomas in a 54-year-old female patient.Case report: Onset at 46 years with bitemporal hemianopsia, without other clinical complaints. MRI conf...

ea0041ep323 | Clinical case reports - Pituitary/Adrenal | ECE2016

Pituitary and legg calvé perthes syndrome – is there a connexion?

Puiu Mirela , Belceanu Alina , Crumpei Iulia , Bursuc Anamaria , Armasu Ioana , Zmau George-Sebastian , Anton Mihaela , Gavrilescu Simona , Vulpoi Carmen

Introduction: Legg calvé perthes (LCP) is a disease characterized by idiopathic avascular necrosis of the proximal femoral epiphysis caused by decreased blood flow. More frequently in boys between 2 and 12 years of age. LCPD is of unknown etiology.We present two male patients of LCP associated with pituitary disorders.Case presentation: Case 1: g.i.c., 8 years 8 month, was first addressed to the endocrinology department for in...

ea0041ep703 | Growth hormone IGF axis - basic | ECE2016

High normal TSH – risk factor for subclinical hypothyroidism in GH treatement for pituitary dwarfism?

Belceanu Alina Daniela , Bursuc Anamaria , Armasu Ioana , Constantinescu Georgiana Andreea , Crumpei Iulia , Leustean Letitia , Anton Mihaela , Vulpoi Carmen

Background: Normal thyroid function is necessary for the optimal effect of recombinant growth hormone (rhGH) on growth rate. GH therapy in children with GH deficiency (GHD) has yielded conflicting results concerning its impact on thyroid function. Data about patients developing subclinical hypothyroidism (SH) are scanty, but it is thought to be associated with impairment of metabolic profile and lower growth response.Objective: To evaluate the effect of ...

ea0041ep945 | Pituitary - Clinical | ECE2016

Sudden global health impairment in a male patient– could it be hypohysitis?

Bursuc Anamaria , Belceanu Alina Daniela , Armasu Ioana , Constantinescu Georgiana Andreea , Esanu Anda , Manciuc Carmen , Crumpei Felicia , Vulpoi Carmen

Introduction: Hypophysitis is a chronic inflammatory condition of the pituitary gland which typically presents with hypopituitarism and a pituitary mass. The disease is rare, with an estimated incidence of 1/9000000. Most reported cases are in women during peripartum period and only approximately 15% of reported cases occur in males.Case report: Male patient, aged 57, smoker, with a history of hypertension, just returned from India, presented with anorex...