Searchable abstracts of presentations at key conferences in endocrinology

ea0019s86 | (1) | SFEBES2009

Jade, sex and a Chinese neolithic culture

Anderson D

I propose to take you on a journey, which started in 2000, when I bought my first Hongshan jade carving, a reproductive piece, in Hong Kong. Since then, as my collection and my obsession have grown at very low financial cost, I have been trying to fathom out why so many ‘experts’ are completely wrong about jade, and especially Neolithic jade. This corner of collecting is truly in the dark ages, where expert opinion rules over evidence, and this is providing me with t...

ea0011p419 | Diabetes, metabolism and cardiovascular | ECE2006

Impact of migration on circulating adipocytokines in an Asian Indian population

Heald AH , Patel J , Prabharakan D , Anderson S , Hughes E , Vyas A , Bhatnagar D , Reddy S , Durrington P , Cruickshank JK

Introduction: Propensity to centripetal adiposity is an ethnic characteristic amongst South Asians, which may underlie the excess risk for both coronary heart disease (CHD) and diabetes in this population. Circulating levels of adipocytokines (hormones which include leptin, adiponectin, tumour necrosis factor (TNF-alpha)) and C-reactive protein (CRP) reflect the adipose tissues endocrine and metabolic activity, and are implicated in CHD.Methods: We compa...

ea0005oc10 | Cardiovascular Endocrinology | BES2003

Genomic analysis of congenic rat strains identifies a new candidate gene for human hypertension

McBride M , Carr F , Graham D , Anderson N , Clark J , Lee W , Charchar F , Brosnan M , Dominiczak A

Objective. The aims of our study were to utilise a combination of high fidelity phenotyping, microarray gene expression profiling and conserved synteny mapping between rodent and human genomes to identify genetic determinants underlying human hypertension.Methods. We used the stroke-prone spontaneously hypertensive rat (SHRSP) and a congenic strain (SP.WKYGla2c*) produced by introgressing a quantitative trait locus responsible for blood pressure regulation on rat chromosom...

ea0011p420 | Diabetes, metabolism and cardiovascular | ECE2006

Migration to the UK results in significantly lower testosterone levels in South Asian men

Patel JV , Panja N , Prabharakan D , Anderson S , Vyas A , Bhatnagar D , Durrington P , Gibson JM , Hughes E , Reddy S , Cruickshank JK , Heald AH

Introduction: Compared to ethnically European men, Pakistani origin men living in the UK have a lower circulating total and free testosterone level, corresponding with greater central adiposity and higher insulin resistance. Within a South Asian group we have now examined the effect of migration to the UK on male testosterone level.Methods: Circulating testosterone concentration was measured by automated immunoassay in 97 Gujarati males resident in India...

ea0029s44.1 | Genome wide studies in reproduction | ICEECE2012

Genome-wide association study of endometriosis identifies a locus at 7p15.2 with pleiotropic effects

Zondervan K. , Painter J. , Rahmioglu N. , Nyholt D. , Anderson C. , MacGregor S. , Lee H. , Visscher P. , Kraft P. , Martin N. , Morris A. , Treloar S. , Kennedy S. , Lindgren C. , Missmer S. , Montgomery G.

Endometriosis is a common gynaecological disease associated with severe pelvic pain and sub-fertility. We conducted a genome-wide association (GWA) study in 3,194 surgically confirmed endometriosis cases and 7060 controls of European ancestry from Australia and the UK using 540,000 genetic markers (SNPs). Polygenic predictive modelling showed significantly increased genetic loading among the 1364 (43%) cases with moderate-severe (rAFS III/IV) endometriosis. The strongest assoc...