ea0086s4.1 | Old hormones, new tricks: new approaches for treating reproductive diseases | SFEBES2022
Hanyroup Sharika
, Anderson Ross
, Nataraja Selvaraj
, Yu Henry
, Kreuchwig Annika
, Krause Gerd
, Katz Arieh
, Millar Robert
, Newton Claire
G protein-coupled receptors (GPCRs) are critical for signal transduction within neuroendocrine signalling pathways, and genetic mutations in G protein-coupled GPCRs underlie numerous diseases. Inactivating GPCR mutations can impede ligand interactions or signal transduction, or can result in misfolding of nascent receptor proteins and subsequent retention in the endoplasmic reticulum (ER) and thus failure to traffic to the cell surface. Examination of the functionality and cel...