Searchable abstracts of presentations at key conferences in endocrinology

ea0077p39 | Metabolism, Obesity and Diabetes | SFEBES2021

Longitudinal clinical trajectory analysis of individuals before and after diagnosis of Type 2 Diabetes Mellitus (T2DM) indicates that vascular problems and asthma pre-date diabetes diagnosis by many years

Heald Adrian , Fachim Helene , Stedman Mike , Gibson Martin , Anderson Simon G , Peng Yonghong , Ollier WiIliam

Introduction: Type 2 diabetes mellitus (T2DM) frequently associates with increasing multi-morbidity/treatment complexity. Some headway has been made to identify genetic and non-genetic risk factors for T2DM. However longitudinal clinical histories of individuals both before and after diagnosis of T2DM are likely to provide additional insight into both diabetes aetiology/further complex trajectory of multi-morbidity.Methods: This study utilised diabetes p...

ea0058p020 | Growth | BSPED2018

The challenges of managing pituitary gigantism

Bendor-Samuel Owen , Pal Aparna , Cudlip Simon , Anderson Gemma , Salgia Sanjay , Makaya Taffy

Introduction: Pituitary gigantism is a rare but clinically significant paediatric condition. Transphenoidal surgery is the treatment of choice, however medical treatment is often considered as adjuvant therapy.Case report: A 10.6 year old boy presented with tall stature. With hindsight he was noticeably tall from age 5 years. At 10 years his height velocity was 12 cm/year, prompting referral and further investigation. His height was 178.7 cm (+5.79 sds a...

ea0030oc1.5 | Oral Communications 1 | BSPED2012

Ethnic differences in vascular growth factor levels in early life in relation to arterial stiffness in the Manchester heart and growth study

Khan Sophia , Anderson Simon , Whatmore Andrew , Pemberton Phillip , Vyas Avni , Cruikshank Kennedy , Clayton Peter

Cardiovascular risk factors are more prevalent in south Asian (SA) adults compared to White Europeans (WE), although the reasons for this are not fully known. Vascular growth factors (VGFs) are increasingly recognised to have various roles in arterial development, function and remodelling. We hypothesised that ethnic differences in VGFs in early life contribute to the later differences in CV risk. We further hypothesised that arterial stiffness, as a measure of large artery st...

ea0028p129 | Cytokines and growth factors | SFEBES2012

Circulating IGF-II concentration is associated with longitudinal increase in high density lipoprotein cholesterol in Type 2 diabetes

Narayanan Ram , Anderson Simon , Fu Bo , Hudson Julie , Oliver Rob , Siddals Kirk , Payton Anthony , Heald Adrian , Ollier William , Gibson John

Associations of Insulin-like growth factor-II with cardiovascular risk have been inadequately studied. We studied longitudinal associations of IGF-II with cardiovascular risk factors in people with type 2 diabetes. Subjects and methods: 462 type-2 diabetes patients aged 26 to 86 years from the Salford Diabetes cohort were analysed. Longitudinal clinical information was extracted (years 2002–2009) from an integrated database of primary care and hospital data. IGF-II was me...

ea0028p130 | Cytokines and growth factors | SFEBES2012

Polymorphisms of the IGFBP3 gene influence circulating IGF-II concentration in type 2 diabetes

Narayanan Ram , Siddals Kirk , Oliver Rob , Hudson Julie , Anderson Simon , Payton Anthony , Heald Adrian , Ollier William , Gibson John

Insulin-like growth factors have fundamental roles in metabolism and apoptosis. Circulating IGF-I and IGF-II are primarily sequestrated with IGFBP-3 in ternary complexes with the acid-labile subunit. We hypothesized that polymorphisms of the IGFBP3 gene may impact circulating IGF-II concentrations.Methods: 478 Caucasian patients were selected from the Salford Diabetes Cohort for analysis. Thirteen haplotype tagging single nucleotide polymorphisms (SNPs) ...

ea0015p252 | Pituitary | SFEBES2008

Adjustment for macroprolactin: an integral part of laboratory assessment of hyperprolactinaemia

Blantern Liz , Qureshi Zubair , Heald Adrian , Anderson Simon , Radford Daniela , Waldron Julian , Davies Marten , McCulloch Alan , Kane John

Background: In most people, prolactin circulates predominantly as a 23-kDa monomer, and a high-molecular-weight form which in the vast majority of cases consists of a complex of prolactin and an anti-prolactin IgG autoantibody, commonly referred to as macroprolactin. This cross-reacts with conventional laboratory assays for prolactin.Report: In a consecutive series of 218 patients with prolactin elevated to 400 μ/l or more in men (normal range &#880...