Endocrine Abstracts

This communication tests the hypothesis that iodine (I2) gas or iodine oxides released from seaweeds previously shown to enhance atmospheric iodine adjacent to seaweed hotspots, may through being inspired by respiration, supply a significant fraction of daily iodine requirements. This could assume importance in a country such as Ireland where iodised salt availability is <5%. Iodine intake was assessed by measuring urinary iodine (UI) excretion using a dry ashing technique...

Objective: Adjuvant chemotherapy is often indicated in patients diagnosed with early breast cancer. Weight gain is one of the observed side effects of both chemotherapy and other cancer treatments, however, the mechanism is not well-described. In this study, we aimed to assess thyroid function before- and after the course of chemotherapy for early breast cancer.Methods: This study is a 5-year prospective cohort study of patients diagnosed with early brea...

Introduction: Aromatase inhibitors, such as Letrozole or Exemestane, are often used as adjuvant treatment for post-menopausal breast cancer. However, they are known to reduce bone mineral density (BMD). Furthermore, breast cancer patients often undergo chemotherapy with drugs associated to BMD loss by themselves. Therefore, patients treated for breast cancer are subject to a considerable risk of BMD loss, and to alleviate this the treatments are normally combined with an anti-...

Background: Breast cancer survivors are a growing population due to improved treatment. It is known that postmenopausal women treated for breast cancer may experience weight gain and increased insulin resistance, but detailed knowledge on how chemotherapy impact metabolic and endocrine mechanisms remain unknown. Objective: We performed a thorough, preliminary study to elucidate the differing mechanisms of post-prandial absorption and metabolism in postme...

Background: Observational studies indicate that breast cancer survivors more often are diagnosed with type 2 diabetes mellitus (T2DM) up to several years after treatment completion. As the population of breast cancer survivors increase due to improved diagnostic and treatment methods the importance of understanding possible long-term side effects of the treatment such as T2DM becomes more central. It is reported that women receiving adjuvant chemotherapy experience weight gain...