Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp51 | Cardiovascular endocrinology | ECE2016

Pericardial rather than intramyocardial fat is independently associated with systolic and diastolic left ventricular heart function in metabolically healthy humans

Wolf Peter , Winhofer Yvonne , Smajis Sabina , Jankovic Drazenka , Anderwald Christian-Heinz , Trattnig Siegfried , Luger Anton , Krebs Michael , Krssak Martin

Background: Obesity is a major risk factor to develop heart failure, in part due to possible lipotoxic effects of increased intramyocardial (MYCL) and/or pericardial (PERI) lipid accumulation. Recent evidence suggests that MYCL is highly dynamic and might rather be a surrogate marker for disturbed energy metabolism than the underlying cause of cardiac dysfunction. On the other hand, PERI might contribute directly by mechanic and paracrine effects. Therefore, we hypothesized th...

ea0035p129 | Calcium and Vitamin D metabolism | ECE2014

Cardio-metabolic phenotyping of patients with familiar hypocalciuric hypercalcemia

Wolf Peter , Krssak Martin , Winhofer Yvonne , Anderwald Christian , Zwettler Elisabeth , Trattnig Siegfried , Luger Anton , Baumgartner-Parzer Sabina , Krebs Michael

Introduction: Heterozygous inactivating mutations of the calcium sensing receptor (CaSR) gene cause mild alterations in calcium metabolism (familiar hypocalciuric hypercalcemia (FHH)). However, in addition to the parathyroid gland CaSR expression was recently identified in the myocardium and many other endocrine cells including pancreatic islet cells, entero-endocine cells and adipose tissue. So far, it is unknown whether FHH is associated with cardio-metabolic altera...

ea0014oc12.1 | Diabetes | ECE2007

Hypoglycemia and cerebral ATP synthesis in Type 1 Diabetes

Mandl Martina , Zbyn Stefan , Mlynarik Vladimir , Promintzer Miriam , Luger Anton , Krebs Michael , Anderwald Christian , Bischof Martin G.

The mechanisms responsible for the progressive failure of hypoglycemia counter-regulation in type-1 diabetes (T1DM) are poorly understood. Alterations of brain energy metabolism could influence glucose sensing by the brain and, thus contribute to hypoglycemia associated autonomic failure. Thus, we measured intraneuronal kinetics of total ATP-synthesis from PCr (kfor) in T1DM patients and effects of hypo/hyperglycemia on this brain energy metabolism. Healthy n...

ea0014p68 | (1) | ECE2007

Circulating retinol binding protein 4 and protein C inhibitor are not related to insulin resistance

Promintzer Miriam , Krebs Michael , Luger Anton , Bischof Martin Georg , Nowotny Peter , Binder Christoph , Esterbauer Harald , Anderwald Christian

Recent data suggest that circulating retinol binding protein-4 (RBP4) is involved in the pathogenesis of insulin resistance in rodents and humans. Moreover, protein C inhibitor (PCI) which specifically binds retinoic acid was found to be increased in myocardial infarction survivors who are also insulin-resistant.Therefore, we investigated the association of insulin resistance with plasma retinol binding factors (RBP4 and PCI active antigen) in nondiabeti...

ea0049ep638 | Growth hormone IGF axis - basic | ECE2017

GH is related to hepatic mitochondrial activity in humans

Wolf Peter , Smajis Sabina , Gajdosiik Martin , Pfleger Lorenz , Winhofer Yvonne , Anderwald Christian-Heinz , Trattnig Siegfried , Luger Anton , Krssak Martin , Krebs Michael

Background: Altered hepatic mitochondrial activity plays a key role in the development of non-alcoholic fatty liver disease (NAFLD). GH has been shown to stimulate mitochondrial function in skeletal muscle. Therefore we hypothesize that the time course of serum GH concentrations during an oral glucose tolerance test might be related to hepatic mitochondrial energy metabolism in vivo in humans.Methods: 15 volunteers (male/female: 7/8; 55±8 y...

ea0014p244 | (1) | ECE2007

Insulin resistance and insulin secretion in morbidly obese patients before and six months after bariatric surgery

Promintzer Miriam , Prager Gerhard , Stadler Marietta , Anderwald Christian , Mandl Martina , Manesch Soheila Shakeri , Nowotny Peter , Bischof Martin Georg , Ludvik Bernhard , Luger Anton , Krebs Michael

Recent case reports describe hyperinsulinemic hypoglycemia after gastric bypass. The aim of this study was the assessment of insulin resistance and insulin secretion in non-diabetic morbidly obese patients before and six months after bariatric surgery.In 8 non-diabetic morbidly obese patients (OB:6f/2 m, age:42±3a, BMI:47.29±2.2 kg/m2) and 6 controls (CON:4f/2 m, age:43±0a, BMI:23.8±0.5 kg/m2) we performed a freq...