Searchable abstracts of presentations at key conferences in endocrinology

ea0038p300 | Pituitary | SFEBES2015

The effect of AIP on AHR transcriptional activity: implications for AIP mutations pathogenicity

de Oliveira Andrade Matheus , Soare Dan Sebastian , Radian Serban , Korbonits Marta

Background: AIP mutations cause sporadic and familial pituitary adenomas, but establishing the pathogenic role of missense AIP variants with unknown significance is difficult. The AIP interaction partner AHR – a xenobiotic-activated transcription factor – regulates transcription of xenobiotic-metabolising enzymes, mediates xenobiotic toxicity, and has been implicated in tumorigenesis.Aim: To describe the effect of AIP...

ea0049oc4.3 | Thyroid Disease 1 | ECE2017

A novel variant in the SERPINA7 gene causing partial TBG deficiency in a women and two male siblings: molecular and protein structural analysis

Lima Cristiane , Maciel Andressa , Cardoso Sarah Caixeta , Andrade Matheus , Cunha Vinicius , Bleicher Lucas , mazzeu Juliana , Lofrano-Porto Adriana

Background: Thyroxine-binding globulin (TBG) is the major human thyroid hormone transport protein. It is encoded by the SERPINA7 gene, located on the long arm of the X chromosome (Xq22.2). Inherited TBG abnormalities result in complete (TBG-CD) or partial (TBG-PD) TBG deficiency. We performed a comprehensive molecular analysis of the SERPINA7 gene in a Brazilian family with TBG-PD.Methods: Genomic DNA was extracted from the female proband, her father, di...

ea0049ep807 | Nuclear receptors and Signal transduction | ECE2017

Cytotoxic activity of plant extracts from Brazilian biome in prostate cancer cell lines

Cardoso Sarah , Andrade Matheus , Cunha Vinicius , Silva Cristian , Rodrigues Patricia , Leao Mayra , Fagg Christopher , Guerra Eliete , Neves Francisco , Simeoni Luiz , Silveira Damaris , Lofrano-Porto Adriana

Introduction: Prostate cancer is a public health problem worldwide. The cure is unlikely and therapeutic alternatives are limited. The Brazilian biodiversity represents a huge source of potential discovery of new drugs derived from plants. We therefore aimed to conduct a biomonitoring chemical study of plant extracts from Pouteria sp. previously shown to be cytotoxic in androgen-sensitive (LNCaP) and androgen-resistant (PC3) human prostate cancer cell lines.<p cla...