ea0016p21 | Adrenal | ECE2008
Mussig Karsten
, Remer Thomas
, Haupt Axel
, Gallwitz Baptist
, Fritsche Andreas
, Haring Hans-Ulrich
, Maser-Gluth Christiane
Objectives: Alterations in glucocorticoid (GC) metabolism may contribute to the development of obesity and insulin resistance. We aimed to study the role of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in human adiposity, paying special attention to the association between altered GC metabolism and insulin sensitivity.Design: In 24-h urine samples of 72 extremely obese (mean BMI 45.5±1.1 kg/m2), but otherwise healthy patie...