ea0099oc1.6 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024
Andreassen Christine Hjorth
, Krarup Knudsen Nadia
, Erik Nielsen John
, Kafai Yahyavi Sam
, Holt Rune
, Jorgensen Anne
, Blomberg Jensen Martin
Currently, no treatment options exist to improve semen quality for the majority of infertile men, but it is well known that the interaction between Sertoli- and germ cells is essential to ensure complete spermatogenesis. A recent study suggested that denosumab, an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL) signaling, may decrease germ cell apoptosis in human ex vivo testis cultures and stimulate sperm production in some infertile men. Her...