Searchable abstracts of presentations at key conferences in endocrinology

ea0099oc1.6 | Oral Communications 1: Reproductive and Developmental Endocrinology | ECE2024

Sertoli cell function and the dose of denosumab is critical for the response to RANKL inhibition in human testis cultures

Andreassen Christine Hjorth , Krarup Knudsen Nadia , Erik Nielsen John , Kafai Yahyavi Sam , Holt Rune , Jorgensen Anne , Blomberg Jensen Martin

Currently, no treatment options exist to improve semen quality for the majority of infertile men, but it is well known that the interaction between Sertoli- and germ cells is essential to ensure complete spermatogenesis. A recent study suggested that denosumab, an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL) signaling, may decrease germ cell apoptosis in human ex vivo testis cultures and stimulate sperm production in some infertile men. Her...