Searchable abstracts of presentations at key conferences in endocrinology

ea0014s14.2 | Trojan horses for steroids | ECE2007

Role of endocytic receptors in cellular uptake of steroid hormones

Willnow Thomas , Hammes Annette , Andreassen Thomas , Nykjaer Anders

Androgens and estrogens are transported bound to the sex hormone binding globulin (SHBG). SHBG is believed to keep sex steroids inactive and to control the amount of free hormones that enter cells by passive diffusion. Contrary to the free hormone hypothesis, we demonstrate that megalin, an endocytic receptor in reproductive tissues acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to SHBG. In line with this function, lack of receptor e...