Searchable abstracts of presentations at key conferences in endocrinology

ea0032p739 | Obesity | ECE2013

Corticotrophin realising factor affects the immune phenotype of adipocytes via CRF1 and CRF2 receptors

Dermitzaki Eirini , Liapakis George , Androulidaki Ariadni , Tsatsanis Christos , Margioris Andrew

Introduction: The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors affect innate immunity. A fully working peripheral CRF system is present in adipose tissue. In obesity, macrophages and adipocytes interact causing local and systemic inflammation. In addition, macrophages and adipocytes share common characteristics including production of inflammatory cytokines in response to lipopolysaccharides (LPS) via the toll-like receptor-4 (TLR4) which b...