Searchable abstracts of presentations at key conferences in endocrinology

ea0013p160 | Diabetes, metabolism and cardiovascular | SFEBES2007

Immunohistochemical localisation of 11β-hydroxysteroid dehydrogenase type 1 in murine pancreatic islets

Swali Angie , Walker Elizabeth , Tomlinson Jeremy , Stewart Paul

The metabolic syndrome, which encompasses features of obesity, insulin resistance, dyslipidaemia and hypertension, has been associated with excessive glucocorticoid (GC) exposure. The pancreas is a target of the adverse affects of GC action, resulting in β-cell damage and reduced glucose-stimulated insulin secretion (GSIS). 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyses the in vivo conversion of inactive to active glucocorticoids (cortisone E/11-de...