Searchable abstracts of presentations at key conferences in endocrinology

ea0002sp10 | Molecular Evolutionary Endocrinology | SFE2001

MOLECULAR EVOLUTION OF GHRH AND PACAP: FUNCTIONAL IMPLICATION FOR THE CONTROL OF GH SECRETION

Montero M , Yon L , Alexandre D , Anouar Y , Chartrel N , Kikuyama S , Dufour S , Vaudry H

Growth hormone-releasing hormone (GHRH) and pituitary adenylate cyclase-activating polypeptide (PACAP) belong to the same superfamily of regulatory neuropeptides which also comprises VIP, glucagon, secretin and GIP. Both GHRH and PACAP have been characterized on the basis of their hypophysiotropic activities. In the course of vertebrate evolution, the primary structure of GHRH has markedly diverged while the sequence of PACAP has been remarkably well preserved. In mammals, GHR...

ea0029oc13.3 | Adrenal Basic | ICEECE2012

Cortisol secretion is dependent on intraadrenal production of ACTH in macronodular bilateral adrenal hyperplasia causing Cushings syndrome

Louiset E. , Duparc C. , Young J. , Boutelet I. , Renouf S. , Bram Z. , Groussin L. , Caron P. , Tabarin A. , Grunenberger F. , Christin-Maitre S. , Kuhn J. , Anouar Y. , Bertherat J. , Lefebvre H.

Illicit expression of membrane receptors for circulating regulatory factors, such as gastric inhibitory polypeptide (GIP), luteinizing hormone (LH) and serotonin (5-HT) receptors, has been well documented in ACTH-independent macronodular adrenal hyperplasias (AIMAHs) causing CushingÂ’s syndrome. In addition, we have observed an abnormal expression of ACTH in some steroidogenic cells in two AIMAH tissues. The aim of the present study was to investigate the role of local pro...