Searchable abstracts of presentations at key conferences in endocrinology

ea0022p169 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Bcl1 polymorphysm of glucocorticoid receptor gene in coronary artery disease

Popovic Bojana , Macut Djuro , Isailovic Tatjana , Bozic Ivana , Antic Jadranka , Ognjanovic Sanja , Petakov Milan , Damjanovic Svetozar

Introduction and aim: Obesity epidemic contributes to the increasing prevalence of high blood sugar, high blood pressure, and dyslipidemia, which are all known risk factors for coronary artery disease (CAD). Metabolic syndrome (MS) describes the common clinical finding wherein component CAD risk factors cluster within a single patient. Since obesity shares common clinical characteristics with both metabolic syndrome (MS) and CushingÂ’s syndrome it is speculated about obeso...

ea0022p557 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Plasma ghrelin concentrations in narcoleptic patients

Lakocevic Milan , Petakov Milan , Rajsic Nenad , Macut Djuro , Antic Jadranka , Popovic Vera , Damjanovic Svetozar

Background: Narcolepsy is hypersomnia of central origin whose clinical features are excessive daytime sleepiness, hypnagogic hallutinations, sleep paralysis and cataplexy which comprises sudden transient loss of muscle tone often triggered by emotions. Narcolepsy with cataplexy is assiociated with hypocretin 1/orexin-A (HCRT 1/ORX-A) deficiency in central nervous system. Because of the link between ghrelin and HCRT 1/ORX-A wake-promoting effects there might be ghrelin deficien...

ea0022p758 | Thyroid | ECE2010

Increased frequency of the glucocorticoid receptor gene polymorphisms in patients with autoimmune thyroid diseases

Antic Jadranka , Petakov Milan , Ognjanovic Sanja , Dragicevic Neda , Lakocevic Milan , Damjanovic Svetozar

Background: Glucocorticoids (GCs) have an important modulatory influence on immune system. GCs accomplish their effects on target tissue through binding to the glucocorticoid receptor (GR). Alterations in glucocorticoid signaling due to polymorphisms of the GR gene may have an impact on the pathophysiology of autoimmune disorders.Aims/methods: We examined the presence of BclI, N363S, A3669G and ER22/23EK GR gene variants in patients with autoimmun...

ea0081rc13.4 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Analysis of the body composition and glucose metabolism in relation to bcli glucocorticoid receptor polymorphism in women with adrenal incidentalomas

Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Elezovic Valentina , Antic Jadranka , Opalic Milica , Radic Lena , Macut Djuro P

Single nucleotide polymorphisms in the glucocorticoid receptor (GR) gene influence tissue sensitivity of GR. Several studies have shown different effects of BclI GR polymorphism on body composition and metabolic parameters. The objective of this study was to explore the effect of BclI GR polymorphism on the body composition and glucose metabolism. Biochemical tests and hormonal evaluation were performed in 106 consecutive women with adrenal incidentalomas (AI...

ea0063p640 | Interdisciplinary Endocrinology 1 | ECE2019

Different regulation of erythropoietin and VEGF in clear renal cell carcinoma

Cokic Bojana Beleslin , Macut Djuro , Milicevic Ivana , Rodic Gordana , Bankovic Jovana , Antic Jadranka , Noguchi Constance , Damjanovic Svetozar

Clear renal cell carcinoma (ccRCC) is a highly vascularized and proliferative tumor. ccRCC can be sporadic or familiar, usually associated with von Hippel-Lindau (VHL) gene mutations. VHL protein is part of the E3 ubiquitin ligase complex that regulates hypoxia-inducible factor (HIF). When a defective and inactive VHL protein is produced, HIF is not degraded, resulting in over-expression of hypoxia related genes including erythropoietin (EPO) and vascular endothelial growth fa...

ea0070aep534 | Endocrine-related Cancer | ECE2020

Diverse regulation of HIF-1 on VEGF in renal cell carcinoma

Beleslin Cokic Bojana , Damjanovic Svetozar , Bizic Radulovic Sandra , Suboticki Tijana , Cokic Vladan , Milicevic Ivana , Rodic Gordana , Antic Jadranka , Macut Djuro

The clear cell renal cell carcinoma (ccRCC) can be sporadic or familiar, with the mutated von Hippel-Lindau (VHL) gene. The inactive VHL protein prevents degradation of hypoxia inducible factor (HIF) that promotes overexpression of angiogenic factors such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO). Sequencing and multiplex ligation-dependent probe amplification (MLPA) of VHL gene in 43 samples of ccRCC in tumors vs surrounding healthy tissues reveale...

ea0014p177 | (1) | ECE2007

Screening for mutations in exon 10, 11, 13 and 14 of the RET protooncogene associated with inherited medullary thiroid carcinoma (MTC) in Serbian population

Nikolic Jelena , Vignjevic Jovana , Mirkovic Katarina , Beleslin-Cokic Bojana , Antic Jadranka , Isailovic Tatjana , Petakov Milan , Damjanovic Svetozar

Background: Ret protooncogene germ-line mutations are associated with the inherited multiple endocrine neoplasia type 2 syndromes (MEN2a and MEN2b) and also with familial medullary thyroid carcinoma (FMTC). In this study, we report a large scale of mutations in exon 10, 11, 13 and 14 RET protoocogene in patients from Serbia. Our study included patients with MTC.Methods: Our study included 180 patients. Patients were tested for RET protooncogene mutations...

ea0014p285 | (1) | ECE2007

Frequency of three major glucocorticoid receptor gene polymorphisms in patients with adrenal incidentalomas

Antic Jadranka , Cokic Bojana Beleslin , Ognjanovic Sanja , Vignjevic Jovana , Mirkovic Katarina , Nikolic Jelena , Paunovic Ivan , Damjanovic Svetozar

Background: Several polymorphisms of glucocorticoid receptor (GR) gene, including BclI, N363S and ER22/23EK, which may have an influence on glucocorticoid sensitivity, have been reported. BclI and N363S polymorphisms have been associated with clinical characteristics of increased and ER22/23EK of decreased glucocorticoid (GC) effects. On the other hand, metabolic syndrome has been described in patients with adrenal incidentalomas.Objective ...

ea0063p57 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Association of the BclI glucocorticoid receptor polymorphism with body composition and metabolic parameters in female patients with adrenal incidentalomas

Ognjanovic Sanja , Macut Djuro , Antic Jadranka , Kovacevic Valentina Elezovic , Isailovic Tatjana , Ilic Dusan , Antic Ivana Bozic , Popovic Bojana , Bogavac Tamara , Damjanovic Svetozar

Interindividual variations in tissue sensitivity to glucocorticoids (GC) have been partly attributed to polymorphisms in the glucocorticoid receptor (GR) gene. The aim of this study was to investigate whether BclI variant of the GR gene may contribute to metabolic abnormalities frequently present in patients with adrenal incidentaloma (AI). Biochemical tests and hormonal evaluation were performed in 106 consecutive women with AI. Non-diabetic patients underwent an ora...

ea0049ep80 | Adrenal cortex (to include Cushing's) | ECE2017

The effect of subclinical hypercortisolism on bone mineral density in female patients with adrenal incidentalomas

Ognjanovic Sanja , Macut Djuro , Petakov Milan , Elezovic Valentina Kovacevic , Isailovic Tatjana , Antic Ivana Bozic , Ilic Dusan , Popovic Bojana , Bogavac Tamara , Antic Jadranka , Damjanovic Svetozar

To investigate the prevalence of SH and osteoporosis in female patients with unilateral AIs (UAIs) and bilateral AIs (BAIs).We enrolled 106 female patients, 68 (64.2%) with UAIs and 47 (35.8%) with BAIs. SH was diagnosed in the presence of serum cortisol levels after 2-day low-dose dexamethasone suppression test (LDDST) >50 nmol/l with at least one of the following parameter (midnight serum cortisol >208 nmol/L, 24-h urinary free cortisol >24...