Endocrine Abstracts

A 19-year-old man attended his optician with an 18-month history of decreased visual acuity. Formal visual field testing revealed significant bitemporal hemianopia. On further questioning in hospital, his voice had deepened only 6 months previously. He had no facial hair. He had no difficulty with erections or libido. He had felt fatigued for months, but had no headaches, weight loss or postural dizziness. There was no history of galactorrhoea, gynaecomastia, nocturia, or exce...

Aim: We aimed to evaluate the usefulness of the Body Image Assessment in Obesity (BIA-O) scale in a UK obesity clinic population by assessing its performance in individuals with a Body Mass Index (BMI) above 50 Kg/m2, evaluating whether obese subjects selected achievable ‘reasonable’ body sizes, and comparing the relationship between body dissatisfaction on the Eating Disorder Inventory-2 (EDI-2) and BIA-O.Methods: Subjects attending...

A 54 year old male was referred for evaluation of Diabetes Insipidus in 2021 with a 12 month history of polyuria, polydipsia and nocturia 3-4 times per night. He always carried water with him and drank 750 ml overnight. He had a history of Ulcerative Colitis, enteropathic osteoarthritis and asthma. He was on Secukinumab monthly. Partial Central Arginine Vasopressin (AVP) deficiency was confirmed by a water deprivation test (serum osmolality >293 mOsm/kg, urine osmolality 3...

A 61-year-old gentleman, with a background of chronic schizophrenia, presented with hyponatraemia in 2008 and was diagnosed with Addison’s disease. He had two previous admissions with hyponatraemia in 2002 and 2006. During his first admission his hyponatraemia was attributed to volume depletion secondary to vomiting, and he responded to fluid resuscitation. On the second occasion, SIADH (syndrome of inappropriate antidiuretic hormone) was diagnosed secondary to antipsycho...

Background: PTMCs are papillary thyroid carcinoma nodules measuring ≤1cm. While the American Thyroid Association (ATA) do not recommend biopsy or follow-up for PTMC nodules, classifying it as a benign condition, some individuals develop cervical lymph node metastases (LNM), challenging its benign classification. Methods: We identified 52 cases of PTMC among 2,000 thyroid patients from 156 MDT meetings at Cork University Hospital (CUH) between Janua...

Follicular thyroid cancer is the second most common cause of thyroid carcinoma. Metastasis occurs in 10–15% of cases. Typical sites of metastasis include bone and lungs, scalp metastasis are rare, with <50 cases reported. We describe two such cases.A retrospective chart review was performed on these patients, examining presentation, treatment and subsequent outcomes.Patient 1. An abnormal lesion was noted on a routine ches...

The British Thyroid Association recommends that a specialist multidisciplinary team (MDT) is responsible for thyroid cancer management. In accordance with this recommendation, a team was formed to manage thyroid carcinoma in a tertiary referral centre. The team included endocrinology, general surgery, ENT, cytology, radiology and radiation oncology consultants.This audit was performed to assess management of thyroid carcinoma before the establishment of ...

Vitamin D insufficiency is common in the Irish population. Patients with primary hyperparathyroidism (PHPT) and co-existing vitamin D insufficiency have higher PTH levels, increased bone turnover and increased risk of postoperative hypocalcaemia. The 3rd International Workshop on PHPT recommended measurement of serum 25-OH Vitamin D in all patients with PHPT, and treatment where required to maintain 25-OH Vitamin D >50 nmol/l. Our study aimed to assess vitamin D status in ...

Multiple endocrine neoplasia type 2a (MEN 2a) is an autosomal dominant disorder with an incidence of ~1 in 30 000 of the population. It is characterized by medullary thyroid cancer (MTC), benign or malignant phaeochromocytomas, and parathyroid hyperplasia or tumours.Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome), is also an autosomal dominant disorder; this condition occurs with an incidence of ~1–2 per 100 000 of the population....

We present a case of a thirty year old female with a history of primary amenorrhoea due to hypogonadotropic hypogonadism (HH) who was further investigated as family history revealed a brother and sister with normosmic hypogonadotropic hypogonadism due to a homozygous pathogenic variant c.1195T>A in the KISS1 receptor gene. Our patient carried the same homozygous mutation, and both parents (unrelated) were heterozygous carriers. KISS1-receptor mutations are a rare cause of ...