Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep323 | Clinical case reports - Pituitary/Adrenal | ECE2016

Pituitary and legg calvé perthes syndrome – is there a connexion?

Puiu Mirela , Belceanu Alina , Crumpei Iulia , Bursuc Anamaria , Armasu Ioana , Zmau George-Sebastian , Anton Mihaela , Gavrilescu Simona , Vulpoi Carmen

Introduction: Legg calvé perthes (LCP) is a disease characterized by idiopathic avascular necrosis of the proximal femoral epiphysis caused by decreased blood flow. More frequently in boys between 2 and 12 years of age. LCPD is of unknown etiology.We present two male patients of LCP associated with pituitary disorders.Case presentation: Case 1: g.i.c., 8 years 8 month, was first addressed to the endocrinology department for in...

ea0041ep703 | Growth hormone IGF axis - basic | ECE2016

High normal TSH – risk factor for subclinical hypothyroidism in GH treatement for pituitary dwarfism?

Belceanu Alina Daniela , Bursuc Anamaria , Armasu Ioana , Constantinescu Georgiana Andreea , Crumpei Iulia , Leustean Letitia , Anton Mihaela , Vulpoi Carmen

Background: Normal thyroid function is necessary for the optimal effect of recombinant growth hormone (rhGH) on growth rate. GH therapy in children with GH deficiency (GHD) has yielded conflicting results concerning its impact on thyroid function. Data about patients developing subclinical hypothyroidism (SH) are scanty, but it is thought to be associated with impairment of metabolic profile and lower growth response.Objective: To evaluate the effect of ...

ea0037ep1343 | Clinical Cases–Thyroid/Other | ECE2015

Concomitance of pancreatic and neuroendocrine breast tumour – simple coincidence or not?

Crumpei Iulia , Fadur Alina , Manolachie Adina , Zmau George , Anton Mihaela , Volovat Constantin , Ungureanu Maria Christina , Vulpoi Carmen

Introduction: Breast neuroendocrine carcinoma is a rare aggressive neuroendocrine tumour (NET) and the research on this subject is poor. Only seven studies were cited in the literature. Incidence in the population has not been reported, but the prevalence is under 0.1% of all breast carcinomas.Case report: AV, 72, is hospitalised for bone pain and significant weight loss (15 kg in 2 months). Patient’s previous history are: diabetes, hypertension, no...

ea0035p814 | Paediatric endocrinology | ECE2014

Differences in skeletal development and growth in children with Noonan syndrome

Fadur Alina Daniela , Rusu Cristina , Anton Mihaela , Bodescu Ioana , Manolachie Adina , Idriceanu Jeanina , Vasiliu Ioana , Ungureanu Maria-Christina , Mogos Voichita , Vulpoi Carmen

Background: Noonan syndrome (NS) is a genetic multisystemic disorder secondary to mutations in Ras/MAPK pathway, essential for cell’s differentiation and growth, patients associating short stature and skeletal anomalies. We describe the alterations in bone development and growth in five children with NS, four of which received treatment with recombinant human GH (rhGH).Methods: We reviewed the cases of five children with NS (three boys, two girls, a...