Endocrine Abstracts

Introduction: Lymphocytic hypophysitis is an uncommon autoimmune disease usually presenting during or just after pregnancy. It may be followed by panhypopituitarism. In such case is extremely rare for a woman to have a normal delivery again.Case report: We report the case of a 28-year-old woman who had a successful delivery 2 years after lymphocytic hypophysitis which had resulted in panhypopituitarism. The young woman presented with amenorrhea, symptoms...

Rationale/Objective: Diabetes Mellitus (DM) and Interstitial lung Disease (ILD) share common pathogenetic pathways involving inflammatory cells and in particular monocytes and macrophages. Diabetic patients are at higher risk of developing pulmonary fibrosis, whereas DM is a major comorbidity in ILD patients. In our study, we analyzed retrospectively patients with ILD and aimed to examine differential characteristics between patients with and without DM, including disease para...

Background: In subjects with long duration of type 2 diabetes (T2DM), strict glycaemic control fails to decrease the incidence of cardiovascular disease (CVD). Impaired vascular indices have been associated with adverse cardiovascular prognosis in T2DM. We examined whether intensive glycaemic control in T2DM patients improves vascular indices.Methods: We studied 68 T2DM patients (64±9 years, 52% males, and T2DM duration 14±10 years) with poor g...

Introduction: The BsmI restriction fragment polymorphism of the vitamin D receptor (VDR) has been related with the development of bone disease in postmenopause, homozygous β thalassemia and hyperthyroidism. The present study aimed to evaluate the association between bone metabolism in patients with epilepsy and the BsmI VDR’s polymorphism.Methods/design: This cross-sectional study evaluated 73 adult patients with epilepsy, under antiepileptic d...

Introduction: Anti-epileptic drugs, usually defined according to their effect on the cytochrome P450 system, might lead to bone mineral density (BMD) decrease and fractures. The anticonvulsant valproate is a hepatic enzyme inhibitor, effective in many types of epilepsy. The present study aimed to assess the impact of long-term valproate monotherapy on BMD in a sample of consecutive ambulatory adult patients with epilepsy.Methods/design: This cross-sectio...

Purpose: The efficacy and safety of RAD, an mTOR inhibitor, in patients with well differentiated metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NET).Material and methods: We studied seven male patients (mean age 55 years, range 36–75) with well differentiated non functioning stage IV GEP-NETs (five pancreatic, one hindgut carcinoid, and one NET of unknown primary). All received RAD 10 mg/day in combination with long acting octerotide 3...

Background: The exact indications and/or the type of operation requiring for the treatment of gastric carcinoids (GC) type 1, are not clearly stated. The present study was designed to evaluate the value of the oncological gastrectomy in the treatment of GC type 1.Materials and method: Between January 2004 and December 2010, we advocated gastric resection in cases of GC type 1 when at least one of the following criteria was present: i) multiple recurrent ...

Case report: We present the case of a patient with somatotroph adenoma combined with neuronal choristoma Pituitary Adenoma Neuronal CHoristoma (PANCH). A female patient, 44 years of age, manifested with acromegaly type features since 1993, while mentioning also headaches, amenorrhea, and peripheral type visual disturbances since 1997. The clinical examination revealed an obese woman with typical acromegalic features. The laboratory evaluation before pituitary surgery showed a ...

Background: The prevalence of incidentally discovered adrenal masses has increased during last decades, due to longer life expectancy and to the extended use of new imaging techniques like high definition C/T and MRI. Diagnostic approach and possible therapeutic management are considered nowadays fascinating challenges for clinical practice, not only for the probability of hormonal hypersecretion but also for the risc of malignancy.Methods: We investigat...

Objective: Bleeding is one of the most dangerous complications following thyroid and parathyroid surgery. For this reason prophylactic perioperative thromboprophylaxis is not routinely use. The aim of this study is to investigate the incidence of clinical and subclinical deep vein thrombosis (DVT) and to validate the Caprini score as a predictive factor of high risk patients after these operations.Material and method: This is a prospective study involvin...