Endocrine Abstracts

Introduction: Hyperandrogenism is a relatively common medical condition, however severe post-menopausal hyperandrogenism should raise suspicion of a malignant etiology and prompt clinical evaluation. Furthermore, androgen excess has also been associated with severely decreased quality of life. As such, identification of its cause and adequate treatment should not be delayed.Case Report: We report a case of a 66-year-old woman, who had a 5-year history of...

Introduction: Graves disease (GD) is a frequent cause of primary hyperthyroidism and often presents with weight loss. Weight gain beyond the premorbid state is often reported and could be a challenge during patient’s management. Treatment modalities, disease remission and biochemical parameters at the diagnosis have been described as predictors of weight changes in patients with GD. Objectives: To evaluate the determinants of weight changes in GD tr...

Introduction: Graves Disease (GD) is an autoimmune disease, in which CD4+ Th2 cells secrete interleucin-4 (IL-4) and IL-5 and activate antibody production. IL-4 has been considered a therapeutic target for treatment of immune-related diseases, by enhancing and redirecting T and B cell function. Dupilumab, a monoclonal antibody, inhibits IL-4 and IL-13 and is currently used for treatment of atopic dermatitis, nasal polyposis and asthma. There is a single case report of painless...

Introduction: Giant prolactinomas (diameter >4 cm) account for less than 5% of all prolactinomas and are usually associated with markedly elevated prolactin (PRL) levels. Despite their benign nature, these tumors can be invasive, potentially leading to mass effect symptoms in affected patients.Case Report: We report a case of a 40-year-old male admitted to the emergency department with a one-week history of headaches, right palpebral edema, and ptosi...

Introduction: Thyroid storm, a life-threatening manifestation of hyperthyroidism, presents a complex clinical challenge that demands swift and precise intervention. The heart is one of the most important target organs affected by the thyrotoxic state. Thyrotoxicosis may lead to sinus tachycardia, hypertension, tachycardiomyopathy, atrial fibrillation and heart failure.Case Presentation: A 46-year-old female presented to the emergency department with symp...

Introduction: Gynecomastia is defined as the benign proliferation of breast tissue in men. Although common, only a small portion of patients seek treatment, either for cosmetic reasons, pain, or tenderness. Tamoxifen has been proposed as an alternative to surgical treatment. Methods : We conducted a retrospective study including all patients referred to our Endocrinology Department between January 2020 and April 2024 due to gynecomastia. Secondary causes...

Introduction: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder known for recurrent arterial and venous thrombotic events. It may involve multiple organ systems, but its impact on the endocrine system is rare. However, the adrenal glands are one of the most susceptible endocrine organs to APS, due to thrombosis, leading to primary adrenal insufficiency (PAI). Most cases are diagnosed in patients with known history of APS.Case Report: We r...

Introduction: Ectopic adrenal tissue (EAT) occurs in less than 1% of adults, more commonly in males. It may be found anywhere along the path of embryogenic migration, usually in the kidney and retroperitoneal fat. We report a case of EAT in the fallopian tube, a particularly rare localization.Case: We present a 57-year-old female with a known medical history of nephrolithiasis and previous ectopic pregnancies. The patient was submitted to a laparoscopic ...

Introduction: Type 2 Diabetes Mellitus (DM2) remission after bariatric surgery can be achieved in 72% of cases. This mechanism is not fully dilucidated; however, it could be caused by the action of glucose direct deposit in the jejunum.Objective: To assess the preoperative eating behavior impact in postoperative DM2 remission.Materials and methods: A retrospective chart review among obese and type 2 diabetic patients that underwent...