Searchable abstracts of presentations at key conferences in endocrinology

ea0016p12 | Adrenal | ECE2008

RNA interference inhibits VEGF and EG-VEGF expression of H295R human adrenocortical carcinoma cell line

Appolloni Gloria , Arnaldi Giorgio , Di Stefano Michele , Spegni Monica , Cardinaletti Marina , Trementino Laura , Boscaro Marco

Background: The development of a vascular supply is a critical factor in the growth and metastatic spread of malignant tumors. The recognition of the vascular endothelial growth factor (VEGF) pathway as a key regulator of angiogenesis has led to a considerable efforts to exploit its potential for therapy in oncology. Endocrine gland-derived (EG-VEGF) has been recently identified as an endothelial cell mitogen, predominantly expressed in steroidogenic tissues; it represents a n...

ea0016p26 | Adrenal | ECE2008

Glucocorticoid receptor gene polymorphisms and bone mineral density in hpa axis disorders

Arnaldi Giorgio , Appolloni Gloria , Romagni Paola , Cardinaletti Marina , Trementino Laura , Polenta Barbara , Concettoni Carolina , Boscaro Marco

Glucocorticoid receptor (GR) gene polymorphisms have been associated with interindividual variations in glucocorticoid sensitivity in healthy individuals.Aim: Aim of this study was to investigate whether there was an association with sensitivity to glucocorticoids and bone mineral density in HPA axis disorders.Methods: We analyzed 3 polymorphisms of the GR gene (Bcl1, N363S, ER22/23EK) in 185 subjects: 52 patients with Cushing&#146...

ea0011p533 | Endocrine tumours and neoplasia | ECE2006

N363S and BclI variants in the glucocorticoid receptor gene and their associations in Cushing’s syndrome and Addison’s disease

Giorgio Arnaldi GA , Gloria Appolloni GA , Claudia Polloni CP , Paola Romagni PR , Barbara Polenta BP , Marina Cardinaletti MC , Alberto Falorni AF , Marco Boscaro MB

Objective: Interindividual variation in glucocorticoid sensitivity can be partly explained by polymorphisms in the GC receptor gene. The most frequent polymorphisms of the GR gene (N363S and BclI) are associated with increased BMI, less lean mass, higher cholesterol and insulin levels. In the present study we investigated the role of the N363S and the BclI polymorphisms in patients with adrenal disease to evaluate their prevalence and the possible clinic and hormone correlatio...