Searchable abstracts of presentations at key conferences in endocrinology

ea0014p379 | (1) | ECE2007

Association of p53 codon 72 polymorphism with thyroid cancer

Caglayan Sinan , Aral Cenk , Massaumilary Sirin , Ozisik Gokhan , Baloglu Huseyin , Akkiprik Mustafa , Ozer Ayse , Ozata Metin

Tumors of thyroid gland are one of the most prevalent forms of human cancers. Despite the various molecular mechanisms, mutations or polymorphisms of p53 have a potential role in the development and/or progression of human malignancies including thyroid. A common variation in p53 that results in adenine to proline change in codon 72 has been identified as a predisposing factor for various cancers since controversial results have been reported. In this study, we investigated co...

ea0056p1149 | Thyroid cancer | ECE2018

The mitochondrial DNA control region might have useful diagnostic and prognostic biomarkers for thyroid tumors

Bircan Rifat , Gozu Hulya Iliksu , Ulu Esra , Sarikaya Sukran , Sirin Duygu Yasar , Ozcelik Serhat , Aral Cenk

Background: It is currently present in the literature that mitochondrial DNA (mtDNA) defects are associated with a great number of diseases including cancers. The role of mitochondrial DNA (mtDNA) mutations/variations in the development of thyroid cancers is a highly controversial topic. In this study, we aimed to investigate the role of mt-DNA control region (CR) variations in thyroid tumor occurrence and the influence of mtDNA haplogroups on susceptibility t...