Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep397 | Clinical case reports - Thyroid/Others | ECE2017

Acquired generalized lipodystrophy associated with latent autoimmune diabetes mellitus in adults: a new metabolic phenotype

Ferrari Federica , Maranghi Marianna , Ceccarini Giovanni , Magno Silvia , Pelosini Caterina , Maffei Margherita , Vitti Paolo , Arca Marcello , Santini Feruccio

Introduction: Acquired generalized lipodystrophies (AGL) are rare syndromes characterized by complete loss of subcutaneous adipose tissue and very low serum leptin levels. AGL are complicated by severe insulin resistance, diabetes mellitus, dyslipidemia and fatty liver. In most patients evidence exists of an autoimmune etiology.Case report: We herein describe the case of a Caucasian woman who was diagnosed with lipodistrophy at 5 years of age, when she b...

ea0056gp69 | Cardiovascular | ECE2018

Can monogenic severe hypertriglyceridemia be differentiated from polygenic forms through clinical features: data from APPROACH and COMPASS studies in FCS and non-FCS hypertriglyceridemic patients?

O'Dea Louis , MacDougall James , Digenio Andres , Hubbard Brant , Arca Marcello , Moriarty Patrick , Kastelein John , Bruckert Eric , Witztum Joseph

Introduction: Differentiation between familial chylomicronemia syndrome (FCS), a rare hypertriglyceridemia, and severe hypertriglyceridemia (sHTG; non-FCS) is challenging due to overlap in triglyceride (TG) levels and symptomology but important in disease management. Clinical characteristics that allow for reliable differentiation may exist in the presenting clinical features and primary diagnostic testing. The objective of this analysis was to assess whether readily obtainabl...

ea0049ep713 | Obesity | ECE2017

Dynapenic obesity and myosteatosis in women with and without the metabolic syndrome

Poggiogalle Eleonora , Donini Lorenzo , Gnessi Lucio , Mariani Stefania , Di Martino Michele , Ciccantelli Barbara , Mancini Cecilia , Arca Marcello , Lenzi Andrea , Lubrano Carla

Introduction: Insulin resistance is a well-known hallmark of the metabolic syndrome (MetS), and it detrimentally affects also protein metabolism, favoring to the decline of lean body mass. The aim of the present study was to explore muscle strength (as a functional consequence of sarcopenic obesity) and muscle quality (namely, myosteatosis) in women with and without the Metabolic Syndrome (MetS).Methods: Study participants were enrolled at the Sapienza U...