Endocrine Abstracts

The complications of endocrine-metabolic disorders among women of reproductive age, such as polycystic ovarian syndrome (PCOS), are cascade of events leading to cardiovascular diseases, as well as non-alcoholic fatty liver disease (NAFLD) which is the leading cause of liver cirrhosis and hepatic carcinoma that often necessitates organ transplant. Paraoxonase-1 (PON-1) has been shown to be protective against metabolic assaults. However, its role in hepatic glucolipid regulation...

Background: Polycystic ovary syndrome (PCOS) is a complex reproductive event that is delineated by endocrine and metabolic disorders. Alteration of kisspeptin status in the hypothalamus and adipose tissue is critical to increased endocrine/metabolic derangements in PCOS individuals, aggravating the clinical manifestation of PCOS and its complications. Short chain fatty acids (SCFAs) are crucial modulators of metabolic homeostasis. However, the role of SCFAs, in particular, ace...

Background: Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. PCOS has been demonstrated to induce depressive-like behavior. Epigenetic alterations such as histone deacetylation (HDAC) and DNA methylation have been suggested in major depression. However, their effects with respect to neuroinflammation are not clear. This study, therefore, investigated the pathogenic role of epigenetic modification in PCOS-associated depre...

Impaired adipose tissue remodeling has been suggested as a pathophysiological driver of endocrinometabolic events in PCOS models, a condition that affects 6-21% of reproductive-aged women worldwide. Mitochondrial dysfunction, especially in the adipocyte plays a key role in adipose tissue inflammation that possibly aggravates endocrine/metabolic phenotypes in PCOS. Studies have reported Short-chain-fatty acids (SCFAs) as metabolic modulators that potentiate energy homeostasis. ...

Background: Polycystic ovarian syndrome (PCOS) is critically characterized with metabolic and endocrine dysfunctions, precipitating metabolic syndrome and infertility in reproductive aged women. Adipose tissue dysfunction has been implicated in the pathogenesis of metabolic syndrome, including in PCOS individuals. Probiotics are healthy bacteria in the gut that regulate metabolic health. However, the impact of probiotics on adipose-driven metabolic syndrome has not been report...

Background: Androgen excess and metabolic abnormality largely contribute to the pathogenesis of PCOS, which primarily precipitates ovarian dysfunction and infertility in reproductive-age women. Impaired mitochondrial function and epigenetic alteration have been linked to the development of PCOS. However, the therapeutic potential of histone deacetylase (HDAC) inhibition on ovarian mitochondrial dysfunction is unclear, especially in PCOS is unclear. Herein, the...

Background: Endocrine-metabolic disorders, especially polycystic ovarian syndrome (PCOS) has been linked with increased risk of non-alcoholic fatty liver disease (NAFLD) among reproductive age and implicated hyperandrogenism-driven adipose/hepatic insulin resistance (IR). Gut microbial metabolites such as short chain fatty acids (SCFAs) are crucial modulators of metabolic regulation. However, the impact of SCFAs, in particular, acetate on hyperandrogenism and/...

Background of Study: Polycystic ovarian syndrome (PCOS) is an endocrine disorder, contributing to increased neurodegenerative disorders including hypothalamic disturbance. Short chain fatty acid (SCFA) has been reported to regulate metabolic health. However, its therapeutic nature in hypothalamic dysfunction, especially in PCOS individuals is unknown. This study hypothesized that SCFA reverses hypothalamic injury and its related abnormalities in experimentally...