Searchable abstracts of presentations at key conferences in endocrinology

ea0034oc6.1 | Clinical | SFEBES2014

Adverse outcome in glucocorticoid induced adrenal suppression; an analysis of short synacthen tests in 2782 patients

Chapman Matthew , Argese Nicola , Mani Dhanasekaran , Dabhi Vijay , Boot Christopher , Crowley Rachel , Stewart Paul , Tomlinson Jeremy

2–3% of the UK population are prescribed glucocorticoid (GC) therapy and their adverse effects contribute to a significant health burden. Suppression of endogenous GC secretion is a recognized complication of therapy, but the magnitude of the problem, together with its clinical consequences have not been determined. We conducted a retrospective study across all specialties in a large secondary–tertiary care center identifying 2782 patients who underwent 3666 250 &#95...

ea0037gp.04.03 | Steroids | ECE2015

Using a morning cortisol to predict adrenal reserve and guide management

Woods Conor , Argese Nicola , Chapman Matthew , Webster Rachel , Toogood Andrew , Arlt Wiebke , Stewart Paul , Crowley Rachel , Tomlinson Jeremy

Background: The short Synacthen test (SST) is the most widely used dynamic assessment of adrenal reserve. In some situations, the SST may be difficult to perform. Random basal cortisol levels could provide an alternative screening assessment to rationalize which patients need dynamic testing. This is highly clinically relevant, given the large numbers of patients taking prescribed glucocorticoids who are at risk of iatrogenic adrenal suppression.Methods:...

ea0016p5 | Adrenal | ECE2008

Modulation of proteomic profile in h295r adrenocortical cell line induced by mitotane

Stigliano Antonio , Cerquetti Lidia , Sampaoli Camilla , Misiti Silvia , Borro Marina , Gentile Giovanna , Argese Nicola , Simmaco Maurizio , Toscano Vincenzo

Background: Mitotane, 1,1-dichloro-2-(o chlorophenyl) -2- (p-chloro phenyl) ethane (o,p′-DDD) is a compound which represents the effective agent in the treatment of the adrenocortical carcinoma (ACC), able to block cortisol synthesis. Nevertheless the biological mechanism induced by this treatment in this cancer remains unknown. Recently, there has been a strong interest in applying proteomics to foster a better understanding of disease proces...

ea0056gp27 | Adrenal clinical | ECE2018

The short synacthen test can be used to predict recovery of hypothalamo-pituitary-adrenal axis function and guide clinical practice

Pofi Riccardo , Feliciano Chona , Sbardella Emilia , Argese Nicola , Woods Conor P , Grossman Ashley B , Jafar-Mohammadi Bahram , Gleeson Helena , Lenzi Andrea , Isidori Andrea M , Tomlinson Jeremy W

The 250 mg short synacthen test (SST) is the most commonly used tool to assess the integrity of hypothalamic-pituitary-adrenal (HPA) axis. There are many instances when compromise to HPA-axis function is potentially reversible (including the use of suppressive dose of prescribed glucocorticoids), but currently there are no data to guide clinicians as to the frequency of repeat testing or to the likelihood of HPA-axis recovery. We performed an observational, retrospective, anal...