ea0032oc2.2 | Bone & Calcium | ECE2013
Jensen Martin Blomberg
, Lieben Liesbet
, Nielsen John E
, Willems Ariane
, Juul Anders
, Jorgensen Niels
, Toppari Jorma
, Carmeliet Geert
, Rajpert-De Meyts Ewa
Introduction: Vitamin D (VD) is metabolized locally in the testis, and ablation of the VD receptor (Vdr−/−) in mice has proven a valid model for hereditary VD resistant rickets. However, only one of three published Vdr−/− strains presented with male infertility. Here, we investigated reproductive hormones, gene expression and the testicular histological phenotype of male Vdr−/−mice,...