ea0025oc3.2 | Pituitary and thyroid | SFEBES2011
El-Farhan Nadia
, Pickett Alan
, Ducroq David
, Bailey Catherine
, Parham Kelly
, Morgan Nicola
, Armston Anne
, Evans Carol
, Rees Dafydd Aled
Introduction and aims: The short Synacthen test (SST) is used to diagnose underactivity of the HPA axis, with a cortisol response <550 nmol/l at 30 min widely accepted as diagnostic of adrenal insufficiency. Earlier studies of the SST have shown variation in cortisol concentrations measured by different immunoassays, suggesting the need for method-specific cut-offs. We sought to define the cortisol response to Synacthen in healthy volunteers (HV) and establish method-speci...